Execution Chart

We display below the execution chart for this examination (boot time has been removed).

Trace from the execution

Formatting '/data/fkordon/mcc2023-input.r234-tall-167856420600647.qcow2', fmt=qcow2 size=4294967296 backing_file=/data/fkordon/mcc2023-input.qcow2 cluster_size=65536 lazy_refcounts=off refcount_bits=16
Waiting for the VM to be ready (probing ssh)
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=====================================================================
Generated by BenchKit 2-5348
Executing tool marciexred
Input is MAPKbis-PT-5320, examination is ReachabilityFireability
Time confinement is 3600 seconds
Memory confinement is 16384 MBytes
Number of cores is 4
Run identifier is r234-tall-167856420600647
=====================================================================

--------------------
preparation of the directory to be used:
/home/mcc/execution
total 768K
-rw-r--r-- 1 mcc users 8.3K Feb 25 16:19 CTLCardinality.txt
-rw-r--r-- 1 mcc users 76K Feb 25 16:19 CTLCardinality.xml
-rw-r--r-- 1 mcc users 11K Feb 25 16:03 CTLFireability.txt
-rw-r--r-- 1 mcc users 47K Feb 25 16:03 CTLFireability.xml
-rw-r--r-- 1 mcc users 4.2K Jan 29 11:40 GenericPropertiesDefinition.xml
-rw-r--r-- 1 mcc users 6.4K Jan 29 11:40 GenericPropertiesVerdict.xml
-rw-r--r-- 1 mcc users 4.3K Feb 25 16:22 LTLCardinality.txt
-rw-r--r-- 1 mcc users 25K Feb 25 16:22 LTLCardinality.xml
-rw-r--r-- 1 mcc users 5.4K Feb 25 16:22 LTLFireability.txt
-rw-r--r-- 1 mcc users 21K Feb 25 16:22 LTLFireability.xml
-rw-r--r-- 1 mcc users 16K Feb 25 16:39 ReachabilityCardinality.txt
-rw-r--r-- 1 mcc users 131K Feb 25 16:39 ReachabilityCardinality.xml
-rw-r--r-- 1 mcc users 40K Feb 25 16:29 ReachabilityFireability.txt
-rw-r--r-- 1 mcc users 153K Feb 25 16:29 ReachabilityFireability.xml
-rw-r--r-- 1 mcc users 1.7K Feb 25 16:22 UpperBounds.txt
-rw-r--r-- 1 mcc users 3.8K Feb 25 16:22 UpperBounds.xml
-rw-r--r-- 1 mcc users 6 Mar 5 18:22 equiv_col
-rw-r--r-- 1 mcc users 5 Mar 5 18:22 instance
-rw-r--r-- 1 mcc users 6 Mar 5 18:22 iscolored
-rw-r--r-- 1 mcc users 170K Mar 5 18:22 model.pnml

--------------------
content from stdout:

=== Data for post analysis generated by BenchKit (invocation template)

The expected result is a vector of booleans
BOOL_VECTOR

here is the order used to build the result vector(from text file)
FORMULA_NAME MAPKbis-PT-5320-ReachabilityFireability-00
FORMULA_NAME MAPKbis-PT-5320-ReachabilityFireability-01
FORMULA_NAME MAPKbis-PT-5320-ReachabilityFireability-02
FORMULA_NAME MAPKbis-PT-5320-ReachabilityFireability-03
FORMULA_NAME MAPKbis-PT-5320-ReachabilityFireability-04
FORMULA_NAME MAPKbis-PT-5320-ReachabilityFireability-05
FORMULA_NAME MAPKbis-PT-5320-ReachabilityFireability-06
FORMULA_NAME MAPKbis-PT-5320-ReachabilityFireability-07
FORMULA_NAME MAPKbis-PT-5320-ReachabilityFireability-08
FORMULA_NAME MAPKbis-PT-5320-ReachabilityFireability-09
FORMULA_NAME MAPKbis-PT-5320-ReachabilityFireability-10
FORMULA_NAME MAPKbis-PT-5320-ReachabilityFireability-11
FORMULA_NAME MAPKbis-PT-5320-ReachabilityFireability-12
FORMULA_NAME MAPKbis-PT-5320-ReachabilityFireability-13
FORMULA_NAME MAPKbis-PT-5320-ReachabilityFireability-14
FORMULA_NAME MAPKbis-PT-5320-ReachabilityFireability-15

=== Now, execution of the tool begins

BK_START 1679546076887

bash -c /home/mcc/BenchKit/BenchKit_head.sh 2> STDERR ; echo ; echo -n "BK_STOP " ; date -u +%s%3N
Invoking MCC driver with
BK_TOOL=marciexred
BK_EXAMINATION=ReachabilityFireability
BK_BIN_PATH=/home/mcc/BenchKit/bin/
BK_TIME_CONFINEMENT=3600
BK_INPUT=MAPKbis-PT-5320
Applying reductions before tool marcie
Invoking reducer
Running Version 202303021504
[2023-03-23 04:34:38] [INFO ] Running its-tools with arguments : [-pnfolder, /home/mcc/execution, -examination, ReachabilityFireability, -timeout, 360, -rebuildPNML]
[2023-03-23 04:34:38] [INFO ] Parsing pnml file : /home/mcc/execution/model.pnml
[2023-03-23 04:34:38] [INFO ] Load time of PNML (sax parser for PT used): 54 ms
[2023-03-23 04:34:38] [INFO ] Transformed 106 places.
[2023-03-23 04:34:38] [INFO ] Transformed 173 transitions.
[2023-03-23 04:34:38] [INFO ] Found NUPN structural information;
[2023-03-23 04:34:38] [INFO ] Parsed PT model containing 106 places and 173 transitions and 986 arcs in 116 ms.
Parsed 16 properties from file /home/mcc/execution/ReachabilityFireability.xml in 15 ms.
Working with output stream class java.io.PrintStream
Deduced a syphon composed of 29 places in 2 ms
Reduce places removed 33 places and 106 transitions.
Reduce places removed 25 places and 0 transitions.
FORMULA MAPKbis-PT-5320-ReachabilityFireability-00 TRUE TECHNIQUES TOPOLOGICAL INITIAL_STATE
FORMULA MAPKbis-PT-5320-ReachabilityFireability-01 FALSE TECHNIQUES TOPOLOGICAL INITIAL_STATE
FORMULA MAPKbis-PT-5320-ReachabilityFireability-04 TRUE TECHNIQUES TOPOLOGICAL INITIAL_STATE
FORMULA MAPKbis-PT-5320-ReachabilityFireability-05 TRUE TECHNIQUES TOPOLOGICAL INITIAL_STATE
FORMULA MAPKbis-PT-5320-ReachabilityFireability-06 TRUE TECHNIQUES TOPOLOGICAL INITIAL_STATE
FORMULA MAPKbis-PT-5320-ReachabilityFireability-07 FALSE TECHNIQUES TOPOLOGICAL INITIAL_STATE
FORMULA MAPKbis-PT-5320-ReachabilityFireability-08 FALSE TECHNIQUES TOPOLOGICAL INITIAL_STATE
FORMULA MAPKbis-PT-5320-ReachabilityFireability-10 FALSE TECHNIQUES TOPOLOGICAL INITIAL_STATE
FORMULA MAPKbis-PT-5320-ReachabilityFireability-11 FALSE TECHNIQUES TOPOLOGICAL INITIAL_STATE
FORMULA MAPKbis-PT-5320-ReachabilityFireability-12 TRUE TECHNIQUES TOPOLOGICAL INITIAL_STATE
FORMULA MAPKbis-PT-5320-ReachabilityFireability-13 FALSE TECHNIQUES TOPOLOGICAL INITIAL_STATE
FORMULA MAPKbis-PT-5320-ReachabilityFireability-14 TRUE TECHNIQUES TOPOLOGICAL INITIAL_STATE
FORMULA MAPKbis-PT-5320-ReachabilityFireability-15 FALSE TECHNIQUES TOPOLOGICAL INITIAL_STATE
Incomplete random walk after 10000 steps, including 289 resets, run finished after 197 ms. (steps per millisecond=50 ) properties (out of 3) seen :1
FORMULA MAPKbis-PT-5320-ReachabilityFireability-09 TRUE TECHNIQUES TOPOLOGICAL RANDOM_WALK
Incomplete Best-First random walk after 10001 steps, including 2 resets, run finished after 30 ms. (steps per millisecond=333 ) properties (out of 2) seen :0
Incomplete Best-First random walk after 10000 steps, including 42 resets, run finished after 30 ms. (steps per millisecond=333 ) properties (out of 2) seen :0
Running SMT prover for 2 properties.
[2023-03-23 04:34:38] [INFO ] Flow matrix only has 47 transitions (discarded 20 similar events)
// Phase 1: matrix 47 rows 48 cols
[2023-03-23 04:34:38] [INFO ] Computed 24 place invariants in 5 ms
[2023-03-23 04:34:39] [INFO ] After 337ms SMT Verify possible using all constraints in real domain returned unsat :0 sat :0 real:2
[2023-03-23 04:34:39] [INFO ] [Nat]Absence check using 24 positive place invariants in 6 ms returned sat
[2023-03-23 04:34:39] [INFO ] After 22ms SMT Verify possible using state equation in natural domain returned unsat :1 sat :1
[2023-03-23 04:34:39] [INFO ] State equation strengthened by 23 read => feed constraints.
[2023-03-23 04:34:39] [INFO ] After 16ms SMT Verify possible using 23 Read/Feed constraints in natural domain returned unsat :1 sat :1
[2023-03-23 04:34:39] [INFO ] After 26ms SMT Verify possible using trap constraints in natural domain returned unsat :1 sat :1
Attempting to minimize the solution found.
Minimization took 9 ms.
[2023-03-23 04:34:39] [INFO ] After 114ms SMT Verify possible using all constraints in natural domain returned unsat :1 sat :1
FORMULA MAPKbis-PT-5320-ReachabilityFireability-03 FALSE TECHNIQUES STRUCTURAL_REDUCTION TOPOLOGICAL SAT_SMT
Fused 2 Parikh solutions to 1 different solutions.
Parikh walk visited 0 properties in 1 ms.
Support contains 6 out of 48 places. Attempting structural reductions.
Starting structural reductions in REACHABILITY mode, iteration 0 : 48/48 places, 67/67 transitions.
Graph (complete) has 125 edges and 48 vertex of which 28 are kept as prefixes of interest. Removing 20 places using SCC suffix rule.0 ms
Discarding 20 places :
Also discarding 6 output transitions
Drop transitions removed 6 transitions
Drop transitions removed 18 transitions
Reduce isomorphic transitions removed 18 transitions.
Iterating post reduction 0 with 18 rules applied. Total rules applied 19 place count 28 transition count 43
Drop transitions removed 2 transitions
Redundant transition composition rules discarded 2 transitions
Iterating global reduction 1 with 2 rules applied. Total rules applied 21 place count 28 transition count 41
Applied a total of 21 rules in 14 ms. Remains 28 /48 variables (removed 20) and now considering 41/67 (removed 26) transitions.
Finished structural reductions in REACHABILITY mode , in 1 iterations and 15 ms. Remains : 28/48 places, 41/67 transitions.
Incomplete random walk after 10000 steps, including 489 resets, run finished after 16 ms. (steps per millisecond=625 ) properties (out of 1) seen :0
Incomplete Best-First random walk after 10001 steps, including 2 resets, run finished after 13 ms. (steps per millisecond=769 ) properties (out of 1) seen :0
Finished probabilistic random walk after 10073 steps, run visited all 1 properties in 28 ms. (steps per millisecond=359 )
Probabilistic random walk after 10073 steps, saw 2680 distinct states, run finished after 28 ms. (steps per millisecond=359 ) properties seen :1
FORMULA MAPKbis-PT-5320-ReachabilityFireability-02 FALSE TECHNIQUES TOPOLOGICAL PROBABILISTIC_WALK
All properties solved without resorting to model-checking.
Total runtime 1025 ms.
timeout --kill-after=10s --signal=SIGINT 1m for testing only

Marcie built on Linux at 2019-11-18.
A model checker for Generalized Stochastic Petri nets

authors: Alex Tovchigrechko (IDD package and CTL model checking)

Martin Schwarick (Symbolic numerical analysis and CSL model checking)

Christian Rohr (Simulative and approximative numerical model checking)

marcie@informatik.tu-cottbus.de

called as: /home/mcc/BenchKit/bin//../reducer/bin//../../marcie/bin/marcie --net-file=model.pnml --mcc-file=ReachabilityFireability.xml --memory=6 --mcc-mode

parse successfull
net created successfully

Net: MAPKbis_PT_5320
(NrP: 106 NrTr: 173 NrArc: 986)

parse formulas
formulas created successfully
place and transition orderings generation:0m 0.002sec

net check time: 0m 0.000sec

init dd package: 0m 2.774sec


RS generation: 0m 0.034sec


-> reachability set: #nodes 235 (2.4e+02) #states 8,126,465 (6)



starting MCC model checker
--------------------------

checking: AG [~ [IS_FIREABLE [RAS_equals_0_to_RAS_equals_1_when_PLCG_equals_1]]]
normalized: ~ [E [true U IS_FIREABLE [RAS_equals_0_to_RAS_equals_1_when_PLCG_equals_1]]]

-> the formula is TRUE

FORMULA MAPKbis-PT-5320-ReachabilityFireability-00 TRUE TECHNIQUES SEQUENTIAL_PROCESSING DECISION_DIAGRAMS UNFOLDING_TO_PT

MC time: 0m 0.000sec

checking: EF [IS_FIREABLE [PI3K_equals_1_to_PI3K_equals_0_when_GAB1_equals_0_and_SOS_equals_0]]
normalized: E [true U IS_FIREABLE [PI3K_equals_1_to_PI3K_equals_0_when_GAB1_equals_0_and_SOS_equals_0]]

-> the formula is FALSE

FORMULA MAPKbis-PT-5320-ReachabilityFireability-07 FALSE TECHNIQUES SEQUENTIAL_PROCESSING DECISION_DIAGRAMS UNFOLDING_TO_PT

MC time: 0m 0.000sec

checking: EF [IS_FIREABLE [RSK_equals_0_to_RSK_equals_1_when_ERK_equals_1]]
normalized: E [true U IS_FIREABLE [RSK_equals_0_to_RSK_equals_1_when_ERK_equals_1]]

-> the formula is FALSE

FORMULA MAPKbis-PT-5320-ReachabilityFireability-08 FALSE TECHNIQUES SEQUENTIAL_PROCESSING DECISION_DIAGRAMS UNFOLDING_TO_PT

MC time: 0m 0.000sec

checking: EF [IS_FIREABLE [p21_equals_1_to_p21_equals_0_when_AKT_equals_1]]
normalized: E [true U IS_FIREABLE [p21_equals_1_to_p21_equals_0_when_AKT_equals_1]]

-> the formula is FALSE

FORMULA MAPKbis-PT-5320-ReachabilityFireability-15 FALSE TECHNIQUES SEQUENTIAL_PROCESSING DECISION_DIAGRAMS UNFOLDING_TO_PT

MC time: 0m 0.000sec

checking: AG [~ [[IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_0_and_TAOK_equals_0] & [[[~ [[IS_FIREABLE [p53_equals_0_to_p53_equals_1_when_ATM_equals_1_and_p38_equals_1] & IS_FIREABLE [FRS2_equals_1_to_FRS2_equals_0_when_GRB2_equals_1]]] & [IS_FIREABLE [EGFR_equals_0_to_EGFR_equals_1_when_EGFR_stimulus_equals_1_and_GRB2_equals_0_and_PKC_equals_0] | IS_FIREABLE [p14_equals_1_to_p14_equals_0_when_MYC_equals_0]]] & [~ [IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_1_and_MDM2_equals_1_and_p38_equals_0]] | [~ [IS_FIREABLE [p38_equals_1_to_p38_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_0_and_TAOK_equals_0]] | ~ [[~ [IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1]] & IS_FIREABLE [PDK1_equals_1_to_PDK1_equals_0_when_PI3K_equals_0]]]]]] | IS_FIREABLE [AKT_equals_1_to_AKT_equals_0_when_PDK1_equals_0]]]]]
normalized: ~ [E [true U [[[[~ [[IS_FIREABLE [p53_equals_0_to_p53_equals_1_when_ATM_equals_1_and_p38_equals_1] & IS_FIREABLE [FRS2_equals_1_to_FRS2_equals_0_when_GRB2_equals_1]]] & [IS_FIREABLE [EGFR_equals_0_to_EGFR_equals_1_when_EGFR_stimulus_equals_1_and_GRB2_equals_0_and_PKC_equals_0] | IS_FIREABLE [p14_equals_1_to_p14_equals_0_when_MYC_equals_0]]] & [[~ [IS_FIREABLE [p38_equals_1_to_p38_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_0_and_TAOK_equals_0]] | ~ [[~ [IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1]] & IS_FIREABLE [PDK1_equals_1_to_PDK1_equals_0_when_PI3K_equals_0]]]] | ~ [IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_1_and_MDM2_equals_1_and_p38_equals_0]]]] | IS_FIREABLE [AKT_equals_1_to_AKT_equals_0_when_PDK1_equals_0]] & IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_0_and_TAOK_equals_0]]]]

-> the formula is FALSE

FORMULA MAPKbis-PT-5320-ReachabilityFireability-02 FALSE TECHNIQUES SEQUENTIAL_PROCESSING DECISION_DIAGRAMS UNFOLDING_TO_PT

MC time: 0m 0.019sec

checking: EF [[[IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_1_and_MDM2_equals_1_and_p38_equals_0] & [[~ [IS_FIREABLE [Proliferation_equals_1_to_Proliferation_equals_0_when_p21_equals_1]] | [~ [[[[IS_FIREABLE [TAOK_equals_0_to_TAOK_equals_1_when_ATM_equals_1] & IS_FIREABLE [BCL2_equals_1_to_BCL2_equals_0_when_AKT_equals_0]] & [IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_0_and_p38_equals_0] & IS_FIREABLE [PTEN_equals_0_to_PTEN_equals_1_when_p53_equals_1]]] & [IS_FIREABLE [SOS_equals_1_to_SOS_equals_0_when_GRB2_equals_0] & ~ [IS_FIREABLE [Apoptosis_equals_0_to_Apoptosis_equals_1_when_BCL2_equals_0_and_ERK_equals_0_and_FOXO3_equals_1_and_p53_equals_1]]]]] & IS_FIREABLE [PI3K_equals_1_to_PI3K_equals_0_when_GAB1_equals_0_and_SOS_equals_0]]] | IS_FIREABLE [p70_equals_1_to_p70_equals_0_when_ERK_equals_0]]] & ~ [[IS_FIREABLE [ERK_equals_0_to_ERK_equals_1_when_MEK1_2_equals_1] | ~ [IS_FIREABLE [GADD45_equals_1_to_GADD45_equals_0_when_SMAD_equals_0_and_p53_equals_0]]]]]]
normalized: E [true U [~ [[~ [IS_FIREABLE [GADD45_equals_1_to_GADD45_equals_0_when_SMAD_equals_0_and_p53_equals_0]] | IS_FIREABLE [ERK_equals_0_to_ERK_equals_1_when_MEK1_2_equals_1]]] & [[[[~ [[[~ [IS_FIREABLE [Apoptosis_equals_0_to_Apoptosis_equals_1_when_BCL2_equals_0_and_ERK_equals_0_and_FOXO3_equals_1_and_p53_equals_1]] & IS_FIREABLE [SOS_equals_1_to_SOS_equals_0_when_GRB2_equals_0]] & [[IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_0_and_p38_equals_0] & IS_FIREABLE [PTEN_equals_0_to_PTEN_equals_1_when_p53_equals_1]] & [IS_FIREABLE [TAOK_equals_0_to_TAOK_equals_1_when_ATM_equals_1] & IS_FIREABLE [BCL2_equals_1_to_BCL2_equals_0_when_AKT_equals_0]]]]] & IS_FIREABLE [PI3K_equals_1_to_PI3K_equals_0_when_GAB1_equals_0_and_SOS_equals_0]] | ~ [IS_FIREABLE [Proliferation_equals_1_to_Proliferation_equals_0_when_p21_equals_1]]] | IS_FIREABLE [p70_equals_1_to_p70_equals_0_when_ERK_equals_0]] & IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_1_and_MDM2_equals_1_and_p38_equals_0]]]]

-> the formula is FALSE

FORMULA MAPKbis-PT-5320-ReachabilityFireability-03 FALSE TECHNIQUES SEQUENTIAL_PROCESSING DECISION_DIAGRAMS UNFOLDING_TO_PT

MC time: 0m 0.000sec

checking: EF [[[[IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAOK_equals_0] & [[IS_FIREABLE [TGFBR_equals_1_to_TGFBR_equals_0_when_TGFBR_stimulus_equals_0] | [~ [[IS_FIREABLE [PTEN_equals_1_to_PTEN_equals_0_when_p53_equals_0] | ~ [IS_FIREABLE [PPP2CA_equals_1_to_PPP2CA_equals_0_when_p38_equals_0]]]] | [IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_JNK_equals_1] | ~ [[IS_FIREABLE [SMAD_equals_1_to_SMAD_equals_0_when_TGFBR_equals_0] | IS_FIREABLE [PPP2CA_equals_1_to_PPP2CA_equals_0_when_p38_equals_0]]]]]] & IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_0]]] & ~ [[IS_FIREABLE [MDM2_equals_1_to_MDM2_equals_0_when_AKT_equals_0_and_p53_equals_0] | ~ [[~ [[IS_FIREABLE [RAF_equals_1_to_RAF_equals_0_when_ERK_equals_1] & IS_FIREABLE [ATM_equals_0_to_ATM_equals_1_when_DNA_damage_equals_1]]] & IS_FIREABLE [AP1_equals_1_to_AP1_equals_0_when_JUN_equals_0]]]]]] | IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1]]]
normalized: E [true U [[~ [[~ [[~ [[IS_FIREABLE [RAF_equals_1_to_RAF_equals_0_when_ERK_equals_1] & IS_FIREABLE [ATM_equals_0_to_ATM_equals_1_when_DNA_damage_equals_1]]] & IS_FIREABLE [AP1_equals_1_to_AP1_equals_0_when_JUN_equals_0]]] | IS_FIREABLE [MDM2_equals_1_to_MDM2_equals_0_when_AKT_equals_0_and_p53_equals_0]]] & [[[[[~ [[IS_FIREABLE [SMAD_equals_1_to_SMAD_equals_0_when_TGFBR_equals_0] | IS_FIREABLE [PPP2CA_equals_1_to_PPP2CA_equals_0_when_p38_equals_0]]] | IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_JNK_equals_1]] | ~ [[~ [IS_FIREABLE [PPP2CA_equals_1_to_PPP2CA_equals_0_when_p38_equals_0]] | IS_FIREABLE [PTEN_equals_1_to_PTEN_equals_0_when_p53_equals_0]]]] | IS_FIREABLE [TGFBR_equals_1_to_TGFBR_equals_0_when_TGFBR_stimulus_equals_0]] & IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_0]] & IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAOK_equals_0]]] | IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1]]]

-> the formula is TRUE

FORMULA MAPKbis-PT-5320-ReachabilityFireability-09 TRUE TECHNIQUES SEQUENTIAL_PROCESSING DECISION_DIAGRAMS UNFOLDING_TO_PT

MC time: 0m 0.019sec

checking: EF [[[[~ [[[[IS_FIREABLE [PTEN_equals_0_to_PTEN_equals_1_when_p53_equals_1] & IS_FIREABLE [Proliferation_equals_0_to_Proliferation_equals_1_when_MYC_equals_1_and_p21_equals_0_and_p70_equals_1]] & ~ [[~ [IS_FIREABLE [Growth_Arrest_equals_0_to_Growth_Arrest_equals_1_when_p21_equals_1]] & [IS_FIREABLE [FOS_equals_0_to_FOS_equals_1_when_CREB_equals_1_and_ERK_equals_1_and_RSK_equals_1] | IS_FIREABLE [MEK1_2_equals_1_to_MEK1_2_equals_0_when_MAP3K1_3_equals_0_and_RAF_equals_0]]]]] | IS_FIREABLE [MEK1_2_equals_1_to_MEK1_2_equals_0_when_MAP3K1_3_equals_0_and_RAF_equals_0]]] & IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_0]] & ~ [[~ [[~ [IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_0_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_0_and_TAOK_equals_0]] & ~ [[[IS_FIREABLE [MTK1_equals_0_to_MTK1_equals_1_when_GADD45_equals_1] & IS_FIREABLE [SPRY_equals_0_to_SPRY_equals_1_when_ERK_equals_1]] & [IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_1] & IS_FIREABLE [AP1_equals_1_to_AP1_equals_0_when_JUN_equals_0]]]]]] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1]]]] & IS_FIREABLE [MAP3K1_3_equals_0_to_MAP3K1_3_equals_1_when_RAS_equals_1]]]
normalized: E [true U [[~ [[IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1] & ~ [[~ [[[IS_FIREABLE [MTK1_equals_0_to_MTK1_equals_1_when_GADD45_equals_1] & IS_FIREABLE [SPRY_equals_0_to_SPRY_equals_1_when_ERK_equals_1]] & [IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_1] & IS_FIREABLE [AP1_equals_1_to_AP1_equals_0_when_JUN_equals_0]]]] & ~ [IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_0_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_0_and_TAOK_equals_0]]]]]] & [~ [[IS_FIREABLE [MEK1_2_equals_1_to_MEK1_2_equals_0_when_MAP3K1_3_equals_0_and_RAF_equals_0] | [~ [[[IS_FIREABLE [FOS_equals_0_to_FOS_equals_1_when_CREB_equals_1_and_ERK_equals_1_and_RSK_equals_1] | IS_FIREABLE [MEK1_2_equals_1_to_MEK1_2_equals_0_when_MAP3K1_3_equals_0_and_RAF_equals_0]] & ~ [IS_FIREABLE [Growth_Arrest_equals_0_to_Growth_Arrest_equals_1_when_p21_equals_1]]]] & [IS_FIREABLE [PTEN_equals_0_to_PTEN_equals_1_when_p53_equals_1] & IS_FIREABLE [Proliferation_equals_0_to_Proliferation_equals_1_when_MYC_equals_1_and_p21_equals_0_and_p70_equals_1]]]]] & IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_0]]] & IS_FIREABLE [MAP3K1_3_equals_0_to_MAP3K1_3_equals_1_when_RAS_equals_1]]]

-> the formula is FALSE

FORMULA MAPKbis-PT-5320-ReachabilityFireability-01 FALSE TECHNIQUES SEQUENTIAL_PROCESSING DECISION_DIAGRAMS UNFOLDING_TO_PT

MC time: 0m 0.000sec

checking: AG [[~ [[~ [[[[IS_FIREABLE [GAB1_equals_1_to_GAB1_equals_0_when_GRB2_equals_0_and_PI3K_equals_0] & ~ [[IS_FIREABLE [FRS2_equals_0_to_FRS2_equals_1_when_FGFR3_equals_1_and_GRB2_equals_0_and_SPRY_equals_0] & IS_FIREABLE [FOS_equals_1_to_FOS_equals_0_when_CREB_equals_0_and_ELK1_equals_0]]]] | ~ [[IS_FIREABLE [TGFBR_equals_1_to_TGFBR_equals_0_when_TGFBR_stimulus_equals_0] & IS_FIREABLE [MSK_equals_1_to_MSK_equals_0_when_ERK_equals_0_and_p38_equals_0]]]] | ~ [[~ [[IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_0_and_MDM2_equals_1] & IS_FIREABLE [RAS_equals_1_to_RAS_equals_0_when_PLCG_equals_0_and_SOS_equals_0]]] & [~ [IS_FIREABLE [MSK_equals_1_to_MSK_equals_0_when_ERK_equals_0_and_p38_equals_0]] | ~ [IS_FIREABLE [TAOK_equals_1_to_TAOK_equals_0_when_ATM_equals_0]]]]]]] & [IS_FIREABLE [p38_equals_1_to_p38_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_0_and_TAK1_equals_0_and_TAOK_equals_0] & [[IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_0] & ~ [[[IS_FIREABLE [FOS_equals_0_to_FOS_equals_1_when_CREB_equals_0_and_ELK1_equals_1_and_ERK_equals_1_and_RSK_equals_1] | IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_1]] & [IS_FIREABLE [MDM2_equals_1_to_MDM2_equals_0_when_p14_equals_1] & IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_0_and_p38_equals_0]]]]] & IS_FIREABLE [RAF_equals_1_to_RAF_equals_0_when_ERK_equals_1]]]]] | IS_FIREABLE [MEK1_2_equals_1_to_MEK1_2_equals_0_when_PPP2CA_equals_1]]]
normalized: ~ [E [true U ~ [[~ [[[[[~ [[[IS_FIREABLE [FOS_equals_0_to_FOS_equals_1_when_CREB_equals_0_and_ELK1_equals_1_and_ERK_equals_1_and_RSK_equals_1] | IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_1]] & [IS_FIREABLE [MDM2_equals_1_to_MDM2_equals_0_when_p14_equals_1] & IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_0_and_p38_equals_0]]]] & IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_0]] & IS_FIREABLE [RAF_equals_1_to_RAF_equals_0_when_ERK_equals_1]] & IS_FIREABLE [p38_equals_1_to_p38_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_0_and_TAK1_equals_0_and_TAOK_equals_0]] & ~ [[~ [[[~ [IS_FIREABLE [TAOK_equals_1_to_TAOK_equals_0_when_ATM_equals_0]] | ~ [IS_FIREABLE [MSK_equals_1_to_MSK_equals_0_when_ERK_equals_0_and_p38_equals_0]]] & ~ [[IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_0_and_MDM2_equals_1] & IS_FIREABLE [RAS_equals_1_to_RAS_equals_0_when_PLCG_equals_0_and_SOS_equals_0]]]]] | [~ [[IS_FIREABLE [TGFBR_equals_1_to_TGFBR_equals_0_when_TGFBR_stimulus_equals_0] & IS_FIREABLE [MSK_equals_1_to_MSK_equals_0_when_ERK_equals_0_and_p38_equals_0]]] | [~ [[IS_FIREABLE [FRS2_equals_0_to_FRS2_equals_1_when_FGFR3_equals_1_and_GRB2_equals_0_and_SPRY_equals_0] & IS_FIREABLE [FOS_equals_1_to_FOS_equals_0_when_CREB_equals_0_and_ELK1_equals_0]]] & IS_FIREABLE [GAB1_equals_1_to_GAB1_equals_0_when_GRB2_equals_0_and_PI3K_equals_0]]]]]]] | IS_FIREABLE [MEK1_2_equals_1_to_MEK1_2_equals_0_when_PPP2CA_equals_1]]]]]

-> the formula is TRUE

FORMULA MAPKbis-PT-5320-ReachabilityFireability-12 TRUE TECHNIQUES SEQUENTIAL_PROCESSING DECISION_DIAGRAMS UNFOLDING_TO_PT

MC time: 0m 0.000sec

checking: EF [[IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAOK_equals_1] & [[[IS_FIREABLE [PPP2CA_equals_1_to_PPP2CA_equals_0_when_p38_equals_0] & [[[[[IS_FIREABLE [FRS2_equals_1_to_FRS2_equals_0_when_SPRY_equals_1] | IS_FIREABLE [FOXO3_equals_1_to_FOXO3_equals_0_when_JNK_equals_0]] | ~ [IS_FIREABLE [TGFBR_equals_0_to_TGFBR_equals_1_when_TGFBR_stimulus_equals_1]]] | [IS_FIREABLE [MEK1_2_equals_0_to_MEK1_2_equals_1_when_AP1_equals_0_and_MAP3K1_3_equals_0_and_PPP2CA_equals_0_and_RAF_equals_1] & ~ [IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1]]]] & [[IS_FIREABLE [MDM2_equals_0_to_MDM2_equals_1_when_AKT_equals_0_and_p14_equals_0_and_p53_equals_1] & IS_FIREABLE [GAB1_equals_0_to_GAB1_equals_1_when_PI3K_equals_1]] | IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1]]] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_MTK1_equals_1]]] | ~ [[~ [[~ [IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_1]] & [IS_FIREABLE [MAX_equals_0_to_MAX_equals_1_when_p38_equals_1] & [IS_FIREABLE [Apoptosis_equals_0_to_Apoptosis_equals_1_when_BCL2_equals_0_and_ERK_equals_0_and_FOXO3_equals_1_and_p53_equals_1] | IS_FIREABLE [Apoptosis_equals_0_to_Apoptosis_equals_1_when_BCL2_equals_0_and_ERK_equals_0_and_FOXO3_equals_1_and_p53_equals_1]]]]] | IS_FIREABLE [Proliferation_equals_1_to_Proliferation_equals_0_when_p70_equals_0]]]] & [~ [[[IS_FIREABLE [FGFR3_equals_1_to_FGFR3_equals_0_when_PKC_equals_1] | [[IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_0_and_TAK1_equals_0_and_TAOK_equals_0] & ~ [IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1]]] & IS_FIREABLE [RAS_equals_0_to_RAS_equals_1_when_PLCG_equals_1]]] & ~ [IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_1]]]] & ~ [[[~ [[[IS_FIREABLE [EGFR_equals_0_to_EGFR_equals_1_when_EGFR_stimulus_equals_1_and_GRB2_equals_0_and_PKC_equals_0] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_1]] | [IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_1_and_MDM2_equals_1_and_p38_equals_0] | IS_FIREABLE [FOS_equals_0_to_FOS_equals_1_when_CREB_equals_1_and_ERK_equals_1_and_RSK_equals_1]]]] & IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_1]] & IS_FIREABLE [MAX_equals_1_to_MAX_equals_0_when_p38_equals_0]]]]]]]
normalized: E [true U [[[~ [[[~ [[[IS_FIREABLE [EGFR_equals_0_to_EGFR_equals_1_when_EGFR_stimulus_equals_1_and_GRB2_equals_0_and_PKC_equals_0] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_1]] | [IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_1_and_MDM2_equals_1_and_p38_equals_0] | IS_FIREABLE [FOS_equals_0_to_FOS_equals_1_when_CREB_equals_1_and_ERK_equals_1_and_RSK_equals_1]]]] & IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_1]] & IS_FIREABLE [MAX_equals_1_to_MAX_equals_0_when_p38_equals_0]]] & ~ [[~ [IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_1]] & [[[~ [IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1]] & IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_0_and_TAK1_equals_0_and_TAOK_equals_0]] & IS_FIREABLE [RAS_equals_0_to_RAS_equals_1_when_PLCG_equals_1]] | IS_FIREABLE [FGFR3_equals_1_to_FGFR3_equals_0_when_PKC_equals_1]]]]] & [~ [[~ [[[[IS_FIREABLE [Apoptosis_equals_0_to_Apoptosis_equals_1_when_BCL2_equals_0_and_ERK_equals_0_and_FOXO3_equals_1_and_p53_equals_1] | IS_FIREABLE [Apoptosis_equals_0_to_Apoptosis_equals_1_when_BCL2_equals_0_and_ERK_equals_0_and_FOXO3_equals_1_and_p53_equals_1]] & IS_FIREABLE [MAX_equals_0_to_MAX_equals_1_when_p38_equals_1]] & ~ [IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_1]]]] | IS_FIREABLE [Proliferation_equals_1_to_Proliferation_equals_0_when_p70_equals_0]]] | [[[[[IS_FIREABLE [MDM2_equals_0_to_MDM2_equals_1_when_AKT_equals_0_and_p14_equals_0_and_p53_equals_1] & IS_FIREABLE [GAB1_equals_0_to_GAB1_equals_1_when_PI3K_equals_1]] | IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1]] & [[~ [IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1]] & IS_FIREABLE [MEK1_2_equals_0_to_MEK1_2_equals_1_when_AP1_equals_0_and_MAP3K1_3_equals_0_and_PPP2CA_equals_0_and_RAF_equals_1]] | [~ [IS_FIREABLE [TGFBR_equals_0_to_TGFBR_equals_1_when_TGFBR_stimulus_equals_1]] | [IS_FIREABLE [FRS2_equals_1_to_FRS2_equals_0_when_SPRY_equals_1] | IS_FIREABLE [FOXO3_equals_1_to_FOXO3_equals_0_when_JNK_equals_0]]]]] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_MTK1_equals_1]] & IS_FIREABLE [PPP2CA_equals_1_to_PPP2CA_equals_0_when_p38_equals_0]]]] & IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAOK_equals_1]]]

-> the formula is FALSE

FORMULA MAPKbis-PT-5320-ReachabilityFireability-13 FALSE TECHNIQUES SEQUENTIAL_PROCESSING DECISION_DIAGRAMS UNFOLDING_TO_PT

MC time: 0m 0.001sec

checking: AG [[~ [IS_FIREABLE [PI3K_equals_1_to_PI3K_equals_0_when_GAB1_equals_0_and_RAS_equals_0]] | [IS_FIREABLE [GRB2_equals_1_to_GRB2_equals_0_when_EGFR_equals_0_and_FRS2_equals_0_and_TGFBR_equals_0] & [~ [[~ [[IS_FIREABLE [MAP3K1_3_equals_0_to_MAP3K1_3_equals_1_when_RAS_equals_1] & [IS_FIREABLE [DUSP1_equals_1_to_DUSP1_equals_0_when_CREB_equals_0] & IS_FIREABLE [SOS_equals_1_to_SOS_equals_0_when_GRB2_equals_0]]]] & [~ [[[IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_JNK_equals_1] & IS_FIREABLE [Apoptosis_equals_0_to_Apoptosis_equals_1_when_BCL2_equals_0_and_ERK_equals_0_and_FOXO3_equals_1_and_p53_equals_1]] | [IS_FIREABLE [MEK1_2_equals_1_to_MEK1_2_equals_0_when_PPP2CA_equals_1] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAOK_equals_1]]]] & ~ [IS_FIREABLE [TGFBR_equals_1_to_TGFBR_equals_0_when_TGFBR_stimulus_equals_0]]]]] & [[[~ [[IS_FIREABLE [p38_equals_1_to_p38_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_0] | IS_FIREABLE [SOS_equals_1_to_SOS_equals_0_when_GRB2_equals_0]]] | [[~ [IS_FIREABLE [MEK1_2_equals_0_to_MEK1_2_equals_1_when_AP1_equals_0_and_MAP3K1_3_equals_1_and_PPP2CA_equals_0]] & [IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_ERK_equals_1] | IS_FIREABLE [ATF2_equals_0_to_ATF2_equals_1_when_p38_equals_1]]] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_1]]] & [[IS_FIREABLE [PI3K_equals_0_to_PI3K_equals_1_when_GAB1_equals_1] | [[IS_FIREABLE [EGFR_equals_1_to_EGFR_equals_0_when_GRB2_equals_1] | IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1]] & [IS_FIREABLE [RAF_equals_0_to_RAF_equals_1_when_AKT_equals_0_and_ERK_equals_0_and_RAS_equals_1] & IS_FIREABLE [PLCG_equals_0_to_PLCG_equals_1_when_EGFR_equals_1]]]] & [[IS_FIREABLE [p53_equals_0_to_p53_equals_1_when_ATM_equals_1_and_MDM2_equals_0] | IS_FIREABLE [p70_equals_1_to_p70_equals_0_when_PDK1_equals_0]] | [[IS_FIREABLE [RSK_equals_0_to_RSK_equals_1_when_ERK_equals_1] | IS_FIREABLE [ATF2_equals_0_to_ATF2_equals_1_when_p38_equals_1]] & [IS_FIREABLE [p53_equals_0_to_p53_equals_1_when_ATM_equals_1_and_MDM2_equals_0] | IS_FIREABLE [RAS_equals_0_to_RAS_equals_1_when_PLCG_equals_1]]]]]] | IS_FIREABLE [FRS2_equals_0_to_FRS2_equals_1_when_FGFR3_equals_1_and_GRB2_equals_0_and_SPRY_equals_0]]]]]]
normalized: ~ [E [true U ~ [[[[[[[[[[IS_FIREABLE [RSK_equals_0_to_RSK_equals_1_when_ERK_equals_1] | IS_FIREABLE [ATF2_equals_0_to_ATF2_equals_1_when_p38_equals_1]] & [IS_FIREABLE [p53_equals_0_to_p53_equals_1_when_ATM_equals_1_and_MDM2_equals_0] | IS_FIREABLE [RAS_equals_0_to_RAS_equals_1_when_PLCG_equals_1]]] | [IS_FIREABLE [p53_equals_0_to_p53_equals_1_when_ATM_equals_1_and_MDM2_equals_0] | IS_FIREABLE [p70_equals_1_to_p70_equals_0_when_PDK1_equals_0]]] & [[[IS_FIREABLE [RAF_equals_0_to_RAF_equals_1_when_AKT_equals_0_and_ERK_equals_0_and_RAS_equals_1] & IS_FIREABLE [PLCG_equals_0_to_PLCG_equals_1_when_EGFR_equals_1]] & [IS_FIREABLE [EGFR_equals_1_to_EGFR_equals_0_when_GRB2_equals_1] | IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1]]] | IS_FIREABLE [PI3K_equals_0_to_PI3K_equals_1_when_GAB1_equals_1]]] & [[[[IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_ERK_equals_1] | IS_FIREABLE [ATF2_equals_0_to_ATF2_equals_1_when_p38_equals_1]] & ~ [IS_FIREABLE [MEK1_2_equals_0_to_MEK1_2_equals_1_when_AP1_equals_0_and_MAP3K1_3_equals_1_and_PPP2CA_equals_0]]] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_1]] | ~ [[IS_FIREABLE [p38_equals_1_to_p38_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_0] | IS_FIREABLE [SOS_equals_1_to_SOS_equals_0_when_GRB2_equals_0]]]]] | IS_FIREABLE [FRS2_equals_0_to_FRS2_equals_1_when_FGFR3_equals_1_and_GRB2_equals_0_and_SPRY_equals_0]] & ~ [[[~ [IS_FIREABLE [TGFBR_equals_1_to_TGFBR_equals_0_when_TGFBR_stimulus_equals_0]] & ~ [[[IS_FIREABLE [MEK1_2_equals_1_to_MEK1_2_equals_0_when_PPP2CA_equals_1] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAOK_equals_1]] | [IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_JNK_equals_1] & IS_FIREABLE [Apoptosis_equals_0_to_Apoptosis_equals_1_when_BCL2_equals_0_and_ERK_equals_0_and_FOXO3_equals_1_and_p53_equals_1]]]]] & ~ [[[IS_FIREABLE [DUSP1_equals_1_to_DUSP1_equals_0_when_CREB_equals_0] & IS_FIREABLE [SOS_equals_1_to_SOS_equals_0_when_GRB2_equals_0]] & IS_FIREABLE [MAP3K1_3_equals_0_to_MAP3K1_3_equals_1_when_RAS_equals_1]]]]]] & IS_FIREABLE [GRB2_equals_1_to_GRB2_equals_0_when_EGFR_equals_0_and_FRS2_equals_0_and_TGFBR_equals_0]] | ~ [IS_FIREABLE [PI3K_equals_1_to_PI3K_equals_0_when_GAB1_equals_0_and_RAS_equals_0]]]]]]

-> the formula is TRUE

FORMULA MAPKbis-PT-5320-ReachabilityFireability-14 TRUE TECHNIQUES SEQUENTIAL_PROCESSING DECISION_DIAGRAMS UNFOLDING_TO_PT

MC time: 0m 0.001sec

checking: AG [[[[[[IS_FIREABLE [PI3K_equals_1_to_PI3K_equals_0_when_GAB1_equals_0_and_RAS_equals_0] & IS_FIREABLE [AKT_equals_0_to_AKT_equals_1_when_PDK1_equals_1_and_PTEN_equals_0]] | ~ [[[[IS_FIREABLE [FGFR3_equals_1_to_FGFR3_equals_0_when_PKC_equals_1] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAK1_equals_1]] | ~ [IS_FIREABLE [Growth_Arrest_equals_0_to_Growth_Arrest_equals_1_when_p21_equals_1]]] | [IS_FIREABLE [p53_equals_0_to_p53_equals_1_when_ATM_equals_1_and_MDM2_equals_0] | [IS_FIREABLE [MDM2_equals_1_to_MDM2_equals_0_when_AKT_equals_0_and_p53_equals_0] | IS_FIREABLE [MYC_equals_0_to_MYC_equals_1_when_AKT_equals_1_and_MSK_equals_1]]]]]] | [IS_FIREABLE [FOXO3_equals_1_to_FOXO3_equals_0_when_AKT_equals_1] | [[IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1] & ~ [[IS_FIREABLE [DUSP1_equals_1_to_DUSP1_equals_0_when_CREB_equals_0] | IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1]]]] & IS_FIREABLE [FRS2_equals_1_to_FRS2_equals_0_when_GRB2_equals_1]]]] | [[[[IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_TAOK_equals_1] & [~ [[IS_FIREABLE [RAF_equals_0_to_RAF_equals_1_when_AKT_equals_0_and_ERK_equals_0_and_PKC_equals_1] | IS_FIREABLE [BCL2_equals_0_to_BCL2_equals_1_when_AKT_equals_1_and_CREB_equals_1]]] & IS_FIREABLE [AP1_equals_0_to_AP1_equals_1_when_ATF2_equals_0_and_FOS_equals_1_and_JUN_equals_1]]] | [[[IS_FIREABLE [MAP3K1_3_equals_1_to_MAP3K1_3_equals_0_when_RAS_equals_0] | ~ [IS_FIREABLE [p53_equals_0_to_p53_equals_1_when_ATM_equals_0_and_MDM2_equals_0_and_p38_equals_1]]] & [[IS_FIREABLE [FRS2_equals_0_to_FRS2_equals_1_when_FGFR3_equals_1_and_GRB2_equals_0_and_SPRY_equals_0] & IS_FIREABLE [MAP3K1_3_equals_1_to_MAP3K1_3_equals_0_when_RAS_equals_0]] & [IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_0_and_TAK1_equals_0_and_TAOK_equals_0] | IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_1_and_MDM2_equals_1_and_p38_equals_0]]]] & [[~ [IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_0_and_MDM2_equals_1]] & ~ [IS_FIREABLE [RAF_equals_0_to_RAF_equals_1_when_AKT_equals_0_and_ERK_equals_0_and_RAS_equals_1]]] | [[IS_FIREABLE [TAOK_equals_1_to_TAOK_equals_0_when_ATM_equals_0] & IS_FIREABLE [p21_equals_1_to_p21_equals_0_when_p53_equals_0]] & [IS_FIREABLE [PTEN_equals_1_to_PTEN_equals_0_when_p53_equals_0] & IS_FIREABLE [EGFR_equals_0_to_EGFR_equals_1_when_EGFR_stimulus_equals_0_and_GRB2_equals_0_and_PKC_equals_0_and_SPRY_equals_1]]]]]] & ~ [IS_FIREABLE [ELK1_equals_1_to_ELK1_equals_0_when_ERK_equals_0_and_JNK_equals_0_and_p38_equals_0]]] | ~ [[[IS_FIREABLE [GRB2_equals_1_to_GRB2_equals_0_when_EGFR_equals_0_and_FRS2_equals_0_and_TGFBR_equals_0] & IS_FIREABLE [RAF_equals_1_to_RAF_equals_0_when_AKT_equals_1]] | [[IS_FIREABLE [BCL2_equals_0_to_BCL2_equals_1_when_AKT_equals_1_and_CREB_equals_1] & IS_FIREABLE [p38_equals_1_to_p38_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAOK_equals_0]] & [IS_FIREABLE [SPRY_equals_0_to_SPRY_equals_1_when_ERK_equals_1] | [IS_FIREABLE [MYC_equals_1_to_MYC_equals_0_when_MSK_equals_0] & [IS_FIREABLE [EGFR_equals_1_to_EGFR_equals_0_when_PKC_equals_1] & IS_FIREABLE [FRS2_equals_1_to_FRS2_equals_0_when_FGFR3_equals_0]]]]]]]]] | IS_FIREABLE [p21_equals_0_to_p21_equals_1_when_AKT_equals_0_and_p53_equals_1]]]
normalized: ~ [E [true U ~ [[[[~ [[[[[[IS_FIREABLE [EGFR_equals_1_to_EGFR_equals_0_when_PKC_equals_1] & IS_FIREABLE [FRS2_equals_1_to_FRS2_equals_0_when_FGFR3_equals_0]] & IS_FIREABLE [MYC_equals_1_to_MYC_equals_0_when_MSK_equals_0]] | IS_FIREABLE [SPRY_equals_0_to_SPRY_equals_1_when_ERK_equals_1]] & [IS_FIREABLE [BCL2_equals_0_to_BCL2_equals_1_when_AKT_equals_1_and_CREB_equals_1] & IS_FIREABLE [p38_equals_1_to_p38_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAOK_equals_0]]] | [IS_FIREABLE [GRB2_equals_1_to_GRB2_equals_0_when_EGFR_equals_0_and_FRS2_equals_0_and_TGFBR_equals_0] & IS_FIREABLE [RAF_equals_1_to_RAF_equals_0_when_AKT_equals_1]]]] | [~ [IS_FIREABLE [ELK1_equals_1_to_ELK1_equals_0_when_ERK_equals_0_and_JNK_equals_0_and_p38_equals_0]] & [[[[[IS_FIREABLE [PTEN_equals_1_to_PTEN_equals_0_when_p53_equals_0] & IS_FIREABLE [EGFR_equals_0_to_EGFR_equals_1_when_EGFR_stimulus_equals_0_and_GRB2_equals_0_and_PKC_equals_0_and_SPRY_equals_1]] & [IS_FIREABLE [TAOK_equals_1_to_TAOK_equals_0_when_ATM_equals_0] & IS_FIREABLE [p21_equals_1_to_p21_equals_0_when_p53_equals_0]]] | [~ [IS_FIREABLE [RAF_equals_0_to_RAF_equals_1_when_AKT_equals_0_and_ERK_equals_0_and_RAS_equals_1]] & ~ [IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_0_and_MDM2_equals_1]]]] & [[[IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_0_and_TAK1_equals_0_and_TAOK_equals_0] | IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_1_and_MDM2_equals_1_and_p38_equals_0]] & [IS_FIREABLE [FRS2_equals_0_to_FRS2_equals_1_when_FGFR3_equals_1_and_GRB2_equals_0_and_SPRY_equals_0] & IS_FIREABLE [MAP3K1_3_equals_1_to_MAP3K1_3_equals_0_when_RAS_equals_0]]] & [~ [IS_FIREABLE [p53_equals_0_to_p53_equals_1_when_ATM_equals_0_and_MDM2_equals_0_and_p38_equals_1]] | IS_FIREABLE [MAP3K1_3_equals_1_to_MAP3K1_3_equals_0_when_RAS_equals_0]]]] | [[~ [[IS_FIREABLE [RAF_equals_0_to_RAF_equals_1_when_AKT_equals_0_and_ERK_equals_0_and_PKC_equals_1] | IS_FIREABLE [BCL2_equals_0_to_BCL2_equals_1_when_AKT_equals_1_and_CREB_equals_1]]] & IS_FIREABLE [AP1_equals_0_to_AP1_equals_1_when_ATF2_equals_0_and_FOS_equals_1_and_JUN_equals_1]] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_TAOK_equals_1]]]]] | [[[[~ [[IS_FIREABLE [DUSP1_equals_1_to_DUSP1_equals_0_when_CREB_equals_0] | IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1]]] & IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1]] & IS_FIREABLE [FRS2_equals_1_to_FRS2_equals_0_when_GRB2_equals_1]] | IS_FIREABLE [FOXO3_equals_1_to_FOXO3_equals_0_when_AKT_equals_1]] | [~ [[[[IS_FIREABLE [MDM2_equals_1_to_MDM2_equals_0_when_AKT_equals_0_and_p53_equals_0] | IS_FIREABLE [MYC_equals_0_to_MYC_equals_1_when_AKT_equals_1_and_MSK_equals_1]] | IS_FIREABLE [p53_equals_0_to_p53_equals_1_when_ATM_equals_1_and_MDM2_equals_0]] | [~ [IS_FIREABLE [Growth_Arrest_equals_0_to_Growth_Arrest_equals_1_when_p21_equals_1]] | [IS_FIREABLE [FGFR3_equals_1_to_FGFR3_equals_0_when_PKC_equals_1] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAK1_equals_1]]]]] | [IS_FIREABLE [PI3K_equals_1_to_PI3K_equals_0_when_GAB1_equals_0_and_RAS_equals_0] & IS_FIREABLE [AKT_equals_0_to_AKT_equals_1_when_PDK1_equals_1_and_PTEN_equals_0]]]]] | IS_FIREABLE [p21_equals_0_to_p21_equals_1_when_AKT_equals_0_and_p53_equals_1]]]]]

-> the formula is TRUE

FORMULA MAPKbis-PT-5320-ReachabilityFireability-06 TRUE TECHNIQUES SEQUENTIAL_PROCESSING DECISION_DIAGRAMS UNFOLDING_TO_PT

MC time: 0m 0.001sec

checking: AG [[[[[[[~ [IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1]] | IS_FIREABLE [EGFR_equals_1_to_EGFR_equals_0_when_PKC_equals_1]] | ~ [IS_FIREABLE [Proliferation_equals_1_to_Proliferation_equals_0_when_MYC_equals_0]]] & [~ [[[IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAOK_equals_0] & IS_FIREABLE [AKT_equals_0_to_AKT_equals_1_when_PDK1_equals_1_and_PTEN_equals_0]] & [IS_FIREABLE [FRS2_equals_1_to_FRS2_equals_0_when_SPRY_equals_1] | [IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_0_and_TAK1_equals_0_and_TAOK_equals_0] | IS_FIREABLE [PI3K_equals_0_to_PI3K_equals_1_when_RAS_equals_1_and_SOS_equals_1]]]]] & [[[[IS_FIREABLE [SPRY_equals_0_to_SPRY_equals_1_when_ERK_equals_1] & IS_FIREABLE [PI3K_equals_1_to_PI3K_equals_0_when_GAB1_equals_0_and_SOS_equals_0]] | ~ [IS_FIREABLE [p38_equals_1_to_p38_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_0_and_TAK1_equals_0_and_TAOK_equals_0]]] & IS_FIREABLE [TAOK_equals_0_to_TAOK_equals_1_when_ATM_equals_1]] & IS_FIREABLE [p53_equals_0_to_p53_equals_1_when_ATM_equals_1_and_p38_equals_1]]]] & [~ [[IS_FIREABLE [FOS_equals_0_to_FOS_equals_1_when_CREB_equals_1_and_ERK_equals_1_and_RSK_equals_1] | IS_FIREABLE [FOXO3_equals_0_to_FOXO3_equals_1_when_AKT_equals_0_and_JNK_equals_1]]] | [~ [[[[IS_FIREABLE [Apoptosis_equals_0_to_Apoptosis_equals_1_when_BCL2_equals_0_and_ERK_equals_0_and_FOXO3_equals_1_and_p53_equals_1] | IS_FIREABLE [ATF2_equals_1_to_ATF2_equals_0_when_JNK_equals_0_and_p38_equals_0]] & [IS_FIREABLE [PPP2CA_equals_1_to_PPP2CA_equals_0_when_p38_equals_0] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1]]] | [~ [IS_FIREABLE [MEK1_2_equals_0_to_MEK1_2_equals_1_when_AP1_equals_0_and_MAP3K1_3_equals_1_and_PPP2CA_equals_0]] | ~ [IS_FIREABLE [SMAD_equals_1_to_SMAD_equals_0_when_TGFBR_equals_0]]]]] & ~ [[~ [IS_FIREABLE [GADD45_equals_0_to_GADD45_equals_1_when_p53_equals_1]] | ~ [IS_FIREABLE [RSK_equals_0_to_RSK_equals_1_when_ERK_equals_1]]]]]]] & ~ [IS_FIREABLE [Proliferation_equals_1_to_Proliferation_equals_0_when_p70_equals_0]]] | [[~ [[[[[IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_JNK_equals_1] | [IS_FIREABLE [TGFBR_equals_0_to_TGFBR_equals_1_when_TGFBR_stimulus_equals_1] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1]]] | [~ [IS_FIREABLE [TGFBR_equals_0_to_TGFBR_equals_1_when_TGFBR_stimulus_equals_1]] & ~ [IS_FIREABLE [PI3K_equals_0_to_PI3K_equals_1_when_GAB1_equals_1]]]] | ~ [[[IS_FIREABLE [FOS_equals_1_to_FOS_equals_0_when_ERK_equals_0] & IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_1_and_MDM2_equals_1_and_p38_equals_0]] & IS_FIREABLE [PLCG_equals_0_to_PLCG_equals_1_when_FGFR3_equals_1]]]] & IS_FIREABLE [p21_equals_1_to_p21_equals_0_when_p53_equals_0]]] | IS_FIREABLE [SMAD_equals_0_to_SMAD_equals_1_when_TGFBR_equals_1]] | ~ [[[IS_FIREABLE [BCL2_equals_0_to_BCL2_equals_1_when_AKT_equals_1_and_CREB_equals_1] & ~ [[~ [IS_FIREABLE [EGFR_equals_1_to_EGFR_equals_0_when_EGFR_stimulus_equals_0_and_SPRY_equals_0]] | [IS_FIREABLE [GRB2_equals_1_to_GRB2_equals_0_when_EGFR_equals_0_and_FRS2_equals_0_and_TGFBR_equals_0] & IS_FIREABLE [MYC_equals_0_to_MYC_equals_1_when_AKT_equals_0_and_MAX_equals_1_and_MSK_equals_1]]]]] | [IS_FIREABLE [PDK1_equals_1_to_PDK1_equals_0_when_PI3K_equals_0] | [[~ [IS_FIREABLE [p53_equals_0_to_p53_equals_1_when_ATM_equals_1_and_p38_equals_1]] | IS_FIREABLE [AP1_equals_1_to_AP1_equals_0_when_JUN_equals_0]] & [[IS_FIREABLE [Growth_Arrest_equals_1_to_Growth_Arrest_equals_0_when_p21_equals_0] & IS_FIREABLE [EGFR_equals_1_to_EGFR_equals_0_when_GRB2_equals_1]] & ~ [IS_FIREABLE [GADD45_equals_0_to_GADD45_equals_1_when_SMAD_equals_1]]]]]]]]]]
normalized: ~ [E [true U ~ [[[~ [[[[[[IS_FIREABLE [Growth_Arrest_equals_1_to_Growth_Arrest_equals_0_when_p21_equals_0] & IS_FIREABLE [EGFR_equals_1_to_EGFR_equals_0_when_GRB2_equals_1]] & ~ [IS_FIREABLE [GADD45_equals_0_to_GADD45_equals_1_when_SMAD_equals_1]]] & [~ [IS_FIREABLE [p53_equals_0_to_p53_equals_1_when_ATM_equals_1_and_p38_equals_1]] | IS_FIREABLE [AP1_equals_1_to_AP1_equals_0_when_JUN_equals_0]]] | IS_FIREABLE [PDK1_equals_1_to_PDK1_equals_0_when_PI3K_equals_0]] | [~ [[[IS_FIREABLE [GRB2_equals_1_to_GRB2_equals_0_when_EGFR_equals_0_and_FRS2_equals_0_and_TGFBR_equals_0] & IS_FIREABLE [MYC_equals_0_to_MYC_equals_1_when_AKT_equals_0_and_MAX_equals_1_and_MSK_equals_1]] | ~ [IS_FIREABLE [EGFR_equals_1_to_EGFR_equals_0_when_EGFR_stimulus_equals_0_and_SPRY_equals_0]]]] & IS_FIREABLE [BCL2_equals_0_to_BCL2_equals_1_when_AKT_equals_1_and_CREB_equals_1]]]] | [~ [[[~ [[[IS_FIREABLE [FOS_equals_1_to_FOS_equals_0_when_ERK_equals_0] & IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_1_and_MDM2_equals_1_and_p38_equals_0]] & IS_FIREABLE [PLCG_equals_0_to_PLCG_equals_1_when_FGFR3_equals_1]]] | [[~ [IS_FIREABLE [PI3K_equals_0_to_PI3K_equals_1_when_GAB1_equals_1]] & ~ [IS_FIREABLE [TGFBR_equals_0_to_TGFBR_equals_1_when_TGFBR_stimulus_equals_1]]] | [[IS_FIREABLE [TGFBR_equals_0_to_TGFBR_equals_1_when_TGFBR_stimulus_equals_1] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1]] | IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_JNK_equals_1]]]] & IS_FIREABLE [p21_equals_1_to_p21_equals_0_when_p53_equals_0]]] | IS_FIREABLE [SMAD_equals_0_to_SMAD_equals_1_when_TGFBR_equals_1]]] | [~ [IS_FIREABLE [Proliferation_equals_1_to_Proliferation_equals_0_when_p70_equals_0]] & [[[~ [[~ [IS_FIREABLE [RSK_equals_0_to_RSK_equals_1_when_ERK_equals_1]] | ~ [IS_FIREABLE [GADD45_equals_0_to_GADD45_equals_1_when_p53_equals_1]]]] & ~ [[[~ [IS_FIREABLE [SMAD_equals_1_to_SMAD_equals_0_when_TGFBR_equals_0]] | ~ [IS_FIREABLE [MEK1_2_equals_0_to_MEK1_2_equals_1_when_AP1_equals_0_and_MAP3K1_3_equals_1_and_PPP2CA_equals_0]]] | [[IS_FIREABLE [PPP2CA_equals_1_to_PPP2CA_equals_0_when_p38_equals_0] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1]] & [IS_FIREABLE [Apoptosis_equals_0_to_Apoptosis_equals_1_when_BCL2_equals_0_and_ERK_equals_0_and_FOXO3_equals_1_and_p53_equals_1] | IS_FIREABLE [ATF2_equals_1_to_ATF2_equals_0_when_JNK_equals_0_and_p38_equals_0]]]]]] | ~ [[IS_FIREABLE [FOS_equals_0_to_FOS_equals_1_when_CREB_equals_1_and_ERK_equals_1_and_RSK_equals_1] | IS_FIREABLE [FOXO3_equals_0_to_FOXO3_equals_1_when_AKT_equals_0_and_JNK_equals_1]]]] & [[[[[~ [IS_FIREABLE [p38_equals_1_to_p38_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_0_and_TAK1_equals_0_and_TAOK_equals_0]] | [IS_FIREABLE [SPRY_equals_0_to_SPRY_equals_1_when_ERK_equals_1] & IS_FIREABLE [PI3K_equals_1_to_PI3K_equals_0_when_GAB1_equals_0_and_SOS_equals_0]]] & IS_FIREABLE [TAOK_equals_0_to_TAOK_equals_1_when_ATM_equals_1]] & IS_FIREABLE [p53_equals_0_to_p53_equals_1_when_ATM_equals_1_and_p38_equals_1]] & ~ [[[IS_FIREABLE [FRS2_equals_1_to_FRS2_equals_0_when_SPRY_equals_1] | [IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_0_and_TAK1_equals_0_and_TAOK_equals_0] | IS_FIREABLE [PI3K_equals_0_to_PI3K_equals_1_when_RAS_equals_1_and_SOS_equals_1]]] & [IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAOK_equals_0] & IS_FIREABLE [AKT_equals_0_to_AKT_equals_1_when_PDK1_equals_1_and_PTEN_equals_0]]]]] & [~ [IS_FIREABLE [Proliferation_equals_1_to_Proliferation_equals_0_when_MYC_equals_0]] | [IS_FIREABLE [EGFR_equals_1_to_EGFR_equals_0_when_PKC_equals_1] | ~ [IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1]]]]]]]]]]]

-> the formula is TRUE

FORMULA MAPKbis-PT-5320-ReachabilityFireability-04 TRUE TECHNIQUES SEQUENTIAL_PROCESSING DECISION_DIAGRAMS UNFOLDING_TO_PT

MC time: 0m 0.001sec

checking: EF [[[IS_FIREABLE [AKT_equals_1_to_AKT_equals_0_when_PDK1_equals_0] | ~ [IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1]]] & [[[[[[[[IS_FIREABLE [MAX_equals_0_to_MAX_equals_1_when_p38_equals_1] | IS_FIREABLE [MYC_equals_0_to_MYC_equals_1_when_AKT_equals_1_and_MSK_equals_1]] | [IS_FIREABLE [FOS_equals_1_to_FOS_equals_0_when_RSK_equals_0] | IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1]]] | IS_FIREABLE [ERK_equals_1_to_ERK_equals_0_when_MEK1_2_equals_0]] | ~ [[[IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAK1_equals_1] & IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_MTK1_equals_1]] | ~ [IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1]]]]] & [[IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1] | [[IS_FIREABLE [MDM2_equals_1_to_MDM2_equals_0_when_AKT_equals_0_and_p53_equals_0] | IS_FIREABLE [GRB2_equals_0_to_GRB2_equals_1_when_TGFBR_equals_1]] | [IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1] | IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_1]]]] | [~ [[IS_FIREABLE [MYC_equals_1_to_MYC_equals_0_when_MSK_equals_0] & IS_FIREABLE [MDM2_equals_1_to_MDM2_equals_0_when_AKT_equals_0_and_p53_equals_0]]] & IS_FIREABLE [Apoptosis_equals_1_to_Apoptosis_equals_0_when_p53_equals_0]]]] & [IS_FIREABLE [RAF_equals_0_to_RAF_equals_1_when_AKT_equals_0_and_ERK_equals_0_and_RAS_equals_1] & [[[[IS_FIREABLE [MSK_equals_1_to_MSK_equals_0_when_ERK_equals_0_and_p38_equals_0] | IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_TAOK_equals_1]] | [IS_FIREABLE [p21_equals_1_to_p21_equals_0_when_p53_equals_0] | IS_FIREABLE [Proliferation_equals_1_to_Proliferation_equals_0_when_p21_equals_1]]] | ~ [IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_JNK_equals_1]]] | ~ [IS_FIREABLE [FOS_equals_1_to_FOS_equals_0_when_RSK_equals_0]]]]] | [[[[IS_FIREABLE [p14_equals_0_to_p14_equals_1_when_MYC_equals_1] | [~ [IS_FIREABLE [MSK_equals_0_to_MSK_equals_1_when_p38_equals_1]] | [IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAK1_equals_1] | IS_FIREABLE [AP1_equals_1_to_AP1_equals_0_when_ATF2_equals_0_and_FOS_equals_0]]]] | [[[IS_FIREABLE [Apoptosis_equals_1_to_Apoptosis_equals_0_when_ERK_equals_1] & IS_FIREABLE [EGFR_equals_1_to_EGFR_equals_0_when_PKC_equals_1]] | ~ [IS_FIREABLE [PI3K_equals_0_to_PI3K_equals_1_when_GAB1_equals_1]]] & IS_FIREABLE [PDK1_equals_1_to_PDK1_equals_0_when_PI3K_equals_0]]] | IS_FIREABLE [RAS_equals_0_to_RAS_equals_1_when_SOS_equals_1]] | [IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_JNK_equals_1] & [~ [[~ [IS_FIREABLE [MTK1_equals_0_to_MTK1_equals_1_when_GADD45_equals_1]] | ~ [IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_ERK_equals_1]]]] & ~ [[IS_FIREABLE [SPRY_equals_1_to_SPRY_equals_0_when_ERK_equals_0] | [IS_FIREABLE [MAX_equals_0_to_MAX_equals_1_when_p38_equals_1] & IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAOK_equals_0]]]]]]]] & [[IS_FIREABLE [FRS2_equals_1_to_FRS2_equals_0_when_SPRY_equals_1] & ~ [[[[IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_0_and_TAK1_equals_0_and_TAOK_equals_0] & [IS_FIREABLE [SPRY_equals_0_to_SPRY_equals_1_when_ERK_equals_1] | IS_FIREABLE [SMAD_equals_0_to_SMAD_equals_1_when_TGFBR_equals_1]]] & [[IS_FIREABLE [PLCG_equals_0_to_PLCG_equals_1_when_FGFR3_equals_1] | IS_FIREABLE [GRB2_equals_0_to_GRB2_equals_1_when_TGFBR_equals_1]] | ~ [IS_FIREABLE [p21_equals_1_to_p21_equals_0_when_p53_equals_0]]]] | [[IS_FIREABLE [Growth_Arrest_equals_1_to_Growth_Arrest_equals_0_when_p21_equals_0] & [IS_FIREABLE [Apoptosis_equals_0_to_Apoptosis_equals_1_when_BCL2_equals_0_and_ERK_equals_0_and_FOXO3_equals_1_and_p53_equals_1] | IS_FIREABLE [GADD45_equals_0_to_GADD45_equals_1_when_SMAD_equals_1]]] & [[IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1] & IS_FIREABLE [GRB2_equals_1_to_GRB2_equals_0_when_EGFR_equals_0_and_FRS2_equals_0_and_TGFBR_equals_0]] | ~ [IS_FIREABLE [Apoptosis_equals_1_to_Apoptosis_equals_0_when_BCL2_equals_1]]]]]]] & [[[[~ [[IS_FIREABLE [EGFR_equals_0_to_EGFR_equals_1_when_EGFR_stimulus_equals_0_and_GRB2_equals_0_and_PKC_equals_0_and_SPRY_equals_1] | IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1]]] & [[IS_FIREABLE [BCL2_equals_0_to_BCL2_equals_1_when_AKT_equals_1_and_CREB_equals_1] | IS_FIREABLE [Proliferation_equals_1_to_Proliferation_equals_0_when_MYC_equals_0]] | IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1]]] | ~ [IS_FIREABLE [p53_equals_0_to_p53_equals_1_when_ATM_equals_1_and_p38_equals_1]]] & ~ [[~ [IS_FIREABLE [CREB_equals_0_to_CREB_equals_1_when_MSK_equals_1]] & ~ [IS_FIREABLE [MYC_equals_0_to_MYC_equals_1_when_AKT_equals_1_and_MSK_equals_1]]]]] | [[[[[IS_FIREABLE [FGFR3_equals_1_to_FGFR3_equals_0_when_FGFR3_stimulus_equals_0] & IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_0_and_p38_equals_0]] | [IS_FIREABLE [p70_equals_0_to_p70_equals_1_when_ERK_equals_1_and_PDK1_equals_1] & IS_FIREABLE [EGFR_equals_1_to_EGFR_equals_0_when_EGFR_stimulus_equals_0_and_SPRY_equals_0]]] & ~ [IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_JNK_equals_1]]] | IS_FIREABLE [TGFBR_equals_1_to_TGFBR_equals_0_when_TGFBR_stimulus_equals_0]] & IS_FIREABLE [MEK1_2_equals_0_to_MEK1_2_equals_1_when_AP1_equals_0_and_MAP3K1_3_equals_1_and_PPP2CA_equals_0]]]]]]]
normalized: E [true U [[[[[[[[[IS_FIREABLE [p70_equals_0_to_p70_equals_1_when_ERK_equals_1_and_PDK1_equals_1] & IS_FIREABLE [EGFR_equals_1_to_EGFR_equals_0_when_EGFR_stimulus_equals_0_and_SPRY_equals_0]] | [IS_FIREABLE [FGFR3_equals_1_to_FGFR3_equals_0_when_FGFR3_stimulus_equals_0] & IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_0_and_p38_equals_0]]] & ~ [IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_JNK_equals_1]]] | IS_FIREABLE [TGFBR_equals_1_to_TGFBR_equals_0_when_TGFBR_stimulus_equals_0]] & IS_FIREABLE [MEK1_2_equals_0_to_MEK1_2_equals_1_when_AP1_equals_0_and_MAP3K1_3_equals_1_and_PPP2CA_equals_0]] | [~ [[~ [IS_FIREABLE [MYC_equals_0_to_MYC_equals_1_when_AKT_equals_1_and_MSK_equals_1]] & ~ [IS_FIREABLE [CREB_equals_0_to_CREB_equals_1_when_MSK_equals_1]]]] & [~ [IS_FIREABLE [p53_equals_0_to_p53_equals_1_when_ATM_equals_1_and_p38_equals_1]] | [[[IS_FIREABLE [BCL2_equals_0_to_BCL2_equals_1_when_AKT_equals_1_and_CREB_equals_1] | IS_FIREABLE [Proliferation_equals_1_to_Proliferation_equals_0_when_MYC_equals_0]] | IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1]] & ~ [[IS_FIREABLE [EGFR_equals_0_to_EGFR_equals_1_when_EGFR_stimulus_equals_0_and_GRB2_equals_0_and_PKC_equals_0_and_SPRY_equals_1] | IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1]]]]]]] & [~ [[[[~ [IS_FIREABLE [Apoptosis_equals_1_to_Apoptosis_equals_0_when_BCL2_equals_1]] | [IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1] & IS_FIREABLE [GRB2_equals_1_to_GRB2_equals_0_when_EGFR_equals_0_and_FRS2_equals_0_and_TGFBR_equals_0]]] & [[IS_FIREABLE [Apoptosis_equals_0_to_Apoptosis_equals_1_when_BCL2_equals_0_and_ERK_equals_0_and_FOXO3_equals_1_and_p53_equals_1] | IS_FIREABLE [GADD45_equals_0_to_GADD45_equals_1_when_SMAD_equals_1]] & IS_FIREABLE [Growth_Arrest_equals_1_to_Growth_Arrest_equals_0_when_p21_equals_0]]] | [[~ [IS_FIREABLE [p21_equals_1_to_p21_equals_0_when_p53_equals_0]] | [IS_FIREABLE [PLCG_equals_0_to_PLCG_equals_1_when_FGFR3_equals_1] | IS_FIREABLE [GRB2_equals_0_to_GRB2_equals_1_when_TGFBR_equals_1]]] & [[IS_FIREABLE [SPRY_equals_0_to_SPRY_equals_1_when_ERK_equals_1] | IS_FIREABLE [SMAD_equals_0_to_SMAD_equals_1_when_TGFBR_equals_1]] & IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_0_and_TAK1_equals_0_and_TAOK_equals_0]]]]] & IS_FIREABLE [FRS2_equals_1_to_FRS2_equals_0_when_SPRY_equals_1]]] & [[[[~ [[[IS_FIREABLE [MAX_equals_0_to_MAX_equals_1_when_p38_equals_1] & IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAOK_equals_0]] | IS_FIREABLE [SPRY_equals_1_to_SPRY_equals_0_when_ERK_equals_0]]] & ~ [[~ [IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_ERK_equals_1]] | ~ [IS_FIREABLE [MTK1_equals_0_to_MTK1_equals_1_when_GADD45_equals_1]]]]] & IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_JNK_equals_1]] | [[[[~ [IS_FIREABLE [PI3K_equals_0_to_PI3K_equals_1_when_GAB1_equals_1]] | [IS_FIREABLE [Apoptosis_equals_1_to_Apoptosis_equals_0_when_ERK_equals_1] & IS_FIREABLE [EGFR_equals_1_to_EGFR_equals_0_when_PKC_equals_1]]] & IS_FIREABLE [PDK1_equals_1_to_PDK1_equals_0_when_PI3K_equals_0]] | [[[IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAK1_equals_1] | IS_FIREABLE [AP1_equals_1_to_AP1_equals_0_when_ATF2_equals_0_and_FOS_equals_0]] | ~ [IS_FIREABLE [MSK_equals_0_to_MSK_equals_1_when_p38_equals_1]]] | IS_FIREABLE [p14_equals_0_to_p14_equals_1_when_MYC_equals_1]]] | IS_FIREABLE [RAS_equals_0_to_RAS_equals_1_when_SOS_equals_1]]] | [[[~ [IS_FIREABLE [FOS_equals_1_to_FOS_equals_0_when_RSK_equals_0]] | [~ [IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_JNK_equals_1]] | [[IS_FIREABLE [p21_equals_1_to_p21_equals_0_when_p53_equals_0] | IS_FIREABLE [Proliferation_equals_1_to_Proliferation_equals_0_when_p21_equals_1]] | [IS_FIREABLE [MSK_equals_1_to_MSK_equals_0_when_ERK_equals_0_and_p38_equals_0] | IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_TAOK_equals_1]]]]] & IS_FIREABLE [RAF_equals_0_to_RAF_equals_1_when_AKT_equals_0_and_ERK_equals_0_and_RAS_equals_1]] & [[[~ [[IS_FIREABLE [MYC_equals_1_to_MYC_equals_0_when_MSK_equals_0] & IS_FIREABLE [MDM2_equals_1_to_MDM2_equals_0_when_AKT_equals_0_and_p53_equals_0]]] & IS_FIREABLE [Apoptosis_equals_1_to_Apoptosis_equals_0_when_p53_equals_0]] | [[[IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1] | IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_1]] | [IS_FIREABLE [MDM2_equals_1_to_MDM2_equals_0_when_AKT_equals_0_and_p53_equals_0] | IS_FIREABLE [GRB2_equals_0_to_GRB2_equals_1_when_TGFBR_equals_1]]] | IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1]]] & [~ [[~ [IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1]] | [IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAK1_equals_1] & IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_MTK1_equals_1]]]] | [[[IS_FIREABLE [FOS_equals_1_to_FOS_equals_0_when_RSK_equals_0] | IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1]] | [IS_FIREABLE [MAX_equals_0_to_MAX_equals_1_when_p38_equals_1] | IS_FIREABLE [MYC_equals_0_to_MYC_equals_1_when_AKT_equals_1_and_MSK_equals_1]]] | IS_FIREABLE [ERK_equals_1_to_ERK_equals_0_when_MEK1_2_equals_0]]]]]]] & [~ [IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1]] | IS_FIREABLE [AKT_equals_1_to_AKT_equals_0_when_PDK1_equals_0]]]]

-> the formula is FALSE

FORMULA MAPKbis-PT-5320-ReachabilityFireability-10 FALSE TECHNIQUES SEQUENTIAL_PROCESSING DECISION_DIAGRAMS UNFOLDING_TO_PT

MC time: 0m 0.002sec

checking: AG [[~ [[~ [IS_FIREABLE [JUN_equals_1_to_JUN_equals_0_when_JNK_equals_0]] | [[~ [[IS_FIREABLE [AKT_equals_1_to_AKT_equals_0_when_PDK1_equals_0] & IS_FIREABLE [TGFBR_equals_0_to_TGFBR_equals_1_when_TGFBR_stimulus_equals_1]]] | [[[IS_FIREABLE [PLCG_equals_1_to_PLCG_equals_0_when_EGFR_equals_0_and_FGFR3_equals_0] | IS_FIREABLE [FOXO3_equals_0_to_FOXO3_equals_1_when_AKT_equals_0_and_JNK_equals_1]] & [IS_FIREABLE [PKC_equals_1_to_PKC_equals_0_when_PLCG_equals_0] | IS_FIREABLE [PLCG_equals_0_to_PLCG_equals_1_when_FGFR3_equals_1]]] & IS_FIREABLE [DUSP1_equals_0_to_DUSP1_equals_1_when_CREB_equals_1]]] | ~ [[IS_FIREABLE [Proliferation_equals_1_to_Proliferation_equals_0_when_p70_equals_0] | [[IS_FIREABLE [TAOK_equals_1_to_TAOK_equals_0_when_ATM_equals_0] & IS_FIREABLE [AP1_equals_0_to_AP1_equals_1_when_ATF2_equals_1_and_JUN_equals_1]] | IS_FIREABLE [GAB1_equals_0_to_GAB1_equals_1_when_PI3K_equals_1]]]]]]] | [[[IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_TAOK_equals_1] | [[[~ [[IS_FIREABLE [PTEN_equals_1_to_PTEN_equals_0_when_p53_equals_0] & IS_FIREABLE [MYC_equals_1_to_MYC_equals_0_when_AKT_equals_0_and_MAX_equals_0]]] & ~ [[IS_FIREABLE [ATF2_equals_0_to_ATF2_equals_1_when_p38_equals_1] & IS_FIREABLE [SOS_equals_1_to_SOS_equals_0_when_GRB2_equals_0]]]] & IS_FIREABLE [TAOK_equals_0_to_TAOK_equals_1_when_ATM_equals_1]] | IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1]]] | [[~ [[IS_FIREABLE [Proliferation_equals_0_to_Proliferation_equals_1_when_MYC_equals_1_and_p21_equals_0_and_p70_equals_1] | [[IS_FIREABLE [p21_equals_1_to_p21_equals_0_when_AKT_equals_1] & IS_FIREABLE [FRS2_equals_1_to_FRS2_equals_0_when_GRB2_equals_1]] & IS_FIREABLE [Proliferation_equals_1_to_Proliferation_equals_0_when_MYC_equals_0]]]] | [[[[IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1] | IS_FIREABLE [TAK1_equals_1_to_TAK1_equals_0_when_TGFBR_equals_0]] | [IS_FIREABLE [MTK1_equals_1_to_MTK1_equals_0_when_GADD45_equals_0] & IS_FIREABLE [MEK1_2_equals_0_to_MEK1_2_equals_1_when_AP1_equals_0_and_MAP3K1_3_equals_1_and_PPP2CA_equals_0]]] & IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_1_and_MDM2_equals_1_and_p38_equals_0]] & [[[IS_FIREABLE [p38_equals_1_to_p38_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_0_and_TAK1_equals_0_and_TAOK_equals_0] & IS_FIREABLE [TGFBR_equals_1_to_TGFBR_equals_0_when_TGFBR_stimulus_equals_0]] & [IS_FIREABLE [PKC_equals_0_to_PKC_equals_1_when_PLCG_equals_1] | IS_FIREABLE [DUSP1_equals_1_to_DUSP1_equals_0_when_CREB_equals_0]]] | [~ [IS_FIREABLE [FOS_equals_0_to_FOS_equals_1_when_CREB_equals_1_and_ERK_equals_1_and_RSK_equals_1]] & [IS_FIREABLE [p70_equals_1_to_p70_equals_0_when_ERK_equals_0] | IS_FIREABLE [p38_equals_1_to_p38_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAOK_equals_0]]]]]] | [~ [[IS_FIREABLE [MSK_equals_1_to_MSK_equals_0_when_ERK_equals_0_and_p38_equals_0] & [IS_FIREABLE [AP1_equals_0_to_AP1_equals_1_when_ATF2_equals_0_and_FOS_equals_1_and_JUN_equals_1] | IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_ERK_equals_1]]]] & [~ [[IS_FIREABLE [FOXO3_equals_1_to_FOXO3_equals_0_when_JNK_equals_0] | [IS_FIREABLE [RAS_equals_0_to_RAS_equals_1_when_SOS_equals_1] | IS_FIREABLE [RAF_equals_0_to_RAF_equals_1_when_AKT_equals_0_and_ERK_equals_0_and_PKC_equals_1]]]] & IS_FIREABLE [FRS2_equals_1_to_FRS2_equals_0_when_GRB2_equals_1]]]]] | [[IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_ERK_equals_1] | [[[~ [[IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAOK_equals_1] & IS_FIREABLE [PTEN_equals_0_to_PTEN_equals_1_when_p53_equals_1]]] & IS_FIREABLE [TAOK_equals_0_to_TAOK_equals_1_when_ATM_equals_1]] | [~ [IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_1_and_TAOK_equals_1]] | ~ [[IS_FIREABLE [RAF_equals_0_to_RAF_equals_1_when_AKT_equals_0_and_ERK_equals_0_and_RAS_equals_1] & IS_FIREABLE [GADD45_equals_1_to_GADD45_equals_0_when_SMAD_equals_0_and_p53_equals_0]]]]] | [[[~ [IS_FIREABLE [TAOK_equals_0_to_TAOK_equals_1_when_ATM_equals_1]] | [IS_FIREABLE [MAX_equals_0_to_MAX_equals_1_when_p38_equals_1] & IS_FIREABLE [FOS_equals_1_to_FOS_equals_0_when_RSK_equals_0]]] & [~ [IS_FIREABLE [PLCG_equals_1_to_PLCG_equals_0_when_EGFR_equals_0_and_FGFR3_equals_0]] | [IS_FIREABLE [PI3K_equals_0_to_PI3K_equals_1_when_GAB1_equals_1] | IS_FIREABLE [AP1_equals_0_to_AP1_equals_1_when_ATF2_equals_1_and_JUN_equals_1]]]] & [[IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_1_and_MDM2_equals_1_and_p38_equals_0] & IS_FIREABLE [FOXO3_equals_0_to_FOXO3_equals_1_when_AKT_equals_0_and_JNK_equals_1]] & IS_FIREABLE [ELK1_equals_1_to_ELK1_equals_0_when_ERK_equals_0_and_JNK_equals_0_and_p38_equals_0]]]]] & [[[IS_FIREABLE [RSK_equals_1_to_RSK_equals_0_when_ERK_equals_0] & [[IS_FIREABLE [MAX_equals_0_to_MAX_equals_1_when_p38_equals_1] & ~ [IS_FIREABLE [CREB_equals_1_to_CREB_equals_0_when_MSK_equals_0]]] | ~ [[IS_FIREABLE [AKT_equals_0_to_AKT_equals_1_when_PDK1_equals_1_and_PTEN_equals_0] | IS_FIREABLE [p14_equals_1_to_p14_equals_0_when_MYC_equals_0]]]]] & [~ [[[IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1] | IS_FIREABLE [GRB2_equals_0_to_GRB2_equals_1_when_EGFR_equals_1]] | [IS_FIREABLE [MAP3K1_3_equals_1_to_MAP3K1_3_equals_0_when_RAS_equals_0] & IS_FIREABLE [MTK1_equals_1_to_MTK1_equals_0_when_GADD45_equals_0]]]] & ~ [[[IS_FIREABLE [Proliferation_equals_0_to_Proliferation_equals_1_when_MYC_equals_1_and_p21_equals_0_and_p70_equals_1] | IS_FIREABLE [p21_equals_1_to_p21_equals_0_when_p53_equals_0]] & [IS_FIREABLE [MDM2_equals_1_to_MDM2_equals_0_when_p14_equals_1] & IS_FIREABLE [Apoptosis_equals_1_to_Apoptosis_equals_0_when_ERK_equals_1]]]]]] | IS_FIREABLE [Growth_Arrest_equals_1_to_Growth_Arrest_equals_0_when_p21_equals_0]]]]]]
normalized: ~ [E [true U ~ [[[[[[[~ [[[IS_FIREABLE [Proliferation_equals_0_to_Proliferation_equals_1_when_MYC_equals_1_and_p21_equals_0_and_p70_equals_1] | IS_FIREABLE [p21_equals_1_to_p21_equals_0_when_p53_equals_0]] & [IS_FIREABLE [MDM2_equals_1_to_MDM2_equals_0_when_p14_equals_1] & IS_FIREABLE [Apoptosis_equals_1_to_Apoptosis_equals_0_when_ERK_equals_1]]]] & ~ [[[IS_FIREABLE [MAP3K1_3_equals_1_to_MAP3K1_3_equals_0_when_RAS_equals_0] & IS_FIREABLE [MTK1_equals_1_to_MTK1_equals_0_when_GADD45_equals_0]] | [IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1] | IS_FIREABLE [GRB2_equals_0_to_GRB2_equals_1_when_EGFR_equals_1]]]]] & [[~ [[IS_FIREABLE [AKT_equals_0_to_AKT_equals_1_when_PDK1_equals_1_and_PTEN_equals_0] | IS_FIREABLE [p14_equals_1_to_p14_equals_0_when_MYC_equals_0]]] | [~ [IS_FIREABLE [CREB_equals_1_to_CREB_equals_0_when_MSK_equals_0]] & IS_FIREABLE [MAX_equals_0_to_MAX_equals_1_when_p38_equals_1]]] & IS_FIREABLE [RSK_equals_1_to_RSK_equals_0_when_ERK_equals_0]]] | IS_FIREABLE [Growth_Arrest_equals_1_to_Growth_Arrest_equals_0_when_p21_equals_0]] & [[[[[IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_1_and_MDM2_equals_1_and_p38_equals_0] & IS_FIREABLE [FOXO3_equals_0_to_FOXO3_equals_1_when_AKT_equals_0_and_JNK_equals_1]] & IS_FIREABLE [ELK1_equals_1_to_ELK1_equals_0_when_ERK_equals_0_and_JNK_equals_0_and_p38_equals_0]] & [[[IS_FIREABLE [PI3K_equals_0_to_PI3K_equals_1_when_GAB1_equals_1] | IS_FIREABLE [AP1_equals_0_to_AP1_equals_1_when_ATF2_equals_1_and_JUN_equals_1]] | ~ [IS_FIREABLE [PLCG_equals_1_to_PLCG_equals_0_when_EGFR_equals_0_and_FGFR3_equals_0]]] & [[IS_FIREABLE [MAX_equals_0_to_MAX_equals_1_when_p38_equals_1] & IS_FIREABLE [FOS_equals_1_to_FOS_equals_0_when_RSK_equals_0]] | ~ [IS_FIREABLE [TAOK_equals_0_to_TAOK_equals_1_when_ATM_equals_1]]]]] | [[~ [[IS_FIREABLE [RAF_equals_0_to_RAF_equals_1_when_AKT_equals_0_and_ERK_equals_0_and_RAS_equals_1] & IS_FIREABLE [GADD45_equals_1_to_GADD45_equals_0_when_SMAD_equals_0_and_p53_equals_0]]] | ~ [IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_1_and_TAOK_equals_1]]] | [~ [[IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAOK_equals_1] & IS_FIREABLE [PTEN_equals_0_to_PTEN_equals_1_when_p53_equals_1]]] & IS_FIREABLE [TAOK_equals_0_to_TAOK_equals_1_when_ATM_equals_1]]]] | IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_ERK_equals_1]]] | [[[[~ [[[IS_FIREABLE [RAS_equals_0_to_RAS_equals_1_when_SOS_equals_1] | IS_FIREABLE [RAF_equals_0_to_RAF_equals_1_when_AKT_equals_0_and_ERK_equals_0_and_PKC_equals_1]] | IS_FIREABLE [FOXO3_equals_1_to_FOXO3_equals_0_when_JNK_equals_0]]] & IS_FIREABLE [FRS2_equals_1_to_FRS2_equals_0_when_GRB2_equals_1]] & ~ [[[IS_FIREABLE [AP1_equals_0_to_AP1_equals_1_when_ATF2_equals_0_and_FOS_equals_1_and_JUN_equals_1] | IS_FIREABLE [ELK1_equals_0_to_ELK1_equals_1_when_ERK_equals_1]] & IS_FIREABLE [MSK_equals_1_to_MSK_equals_0_when_ERK_equals_0_and_p38_equals_0]]]] | [[[[[IS_FIREABLE [p70_equals_1_to_p70_equals_0_when_ERK_equals_0] | IS_FIREABLE [p38_equals_1_to_p38_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAOK_equals_0]] & ~ [IS_FIREABLE [FOS_equals_0_to_FOS_equals_1_when_CREB_equals_1_and_ERK_equals_1_and_RSK_equals_1]]] | [[IS_FIREABLE [PKC_equals_0_to_PKC_equals_1_when_PLCG_equals_1] | IS_FIREABLE [DUSP1_equals_1_to_DUSP1_equals_0_when_CREB_equals_0]] & [IS_FIREABLE [p38_equals_1_to_p38_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_0_and_TAK1_equals_0_and_TAOK_equals_0] & IS_FIREABLE [TGFBR_equals_1_to_TGFBR_equals_0_when_TGFBR_stimulus_equals_0]]]] & [[[IS_FIREABLE [MTK1_equals_1_to_MTK1_equals_0_when_GADD45_equals_0] & IS_FIREABLE [MEK1_2_equals_0_to_MEK1_2_equals_1_when_AP1_equals_0_and_MAP3K1_3_equals_1_and_PPP2CA_equals_0]] | [IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1] | IS_FIREABLE [TAK1_equals_1_to_TAK1_equals_0_when_TGFBR_equals_0]]] & IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_1_and_MDM2_equals_1_and_p38_equals_0]]] | ~ [[[[IS_FIREABLE [p21_equals_1_to_p21_equals_0_when_AKT_equals_1] & IS_FIREABLE [FRS2_equals_1_to_FRS2_equals_0_when_GRB2_equals_1]] & IS_FIREABLE [Proliferation_equals_1_to_Proliferation_equals_0_when_MYC_equals_0]] | IS_FIREABLE [Proliferation_equals_0_to_Proliferation_equals_1_when_MYC_equals_1_and_p21_equals_0_and_p70_equals_1]]]]] | [[[[~ [[IS_FIREABLE [ATF2_equals_0_to_ATF2_equals_1_when_p38_equals_1] & IS_FIREABLE [SOS_equals_1_to_SOS_equals_0_when_GRB2_equals_0]]] & ~ [[IS_FIREABLE [PTEN_equals_1_to_PTEN_equals_0_when_p53_equals_0] & IS_FIREABLE [MYC_equals_1_to_MYC_equals_0_when_AKT_equals_0_and_MAX_equals_0]]]] & IS_FIREABLE [TAOK_equals_0_to_TAOK_equals_1_when_ATM_equals_1]] | IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1]] | IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_TAOK_equals_1]]]] | ~ [[[~ [[[[IS_FIREABLE [TAOK_equals_1_to_TAOK_equals_0_when_ATM_equals_0] & IS_FIREABLE [AP1_equals_0_to_AP1_equals_1_when_ATF2_equals_1_and_JUN_equals_1]] | IS_FIREABLE [GAB1_equals_0_to_GAB1_equals_1_when_PI3K_equals_1]] | IS_FIREABLE [Proliferation_equals_1_to_Proliferation_equals_0_when_p70_equals_0]]] | [[[[IS_FIREABLE [PKC_equals_1_to_PKC_equals_0_when_PLCG_equals_0] | IS_FIREABLE [PLCG_equals_0_to_PLCG_equals_1_when_FGFR3_equals_1]] & [IS_FIREABLE [PLCG_equals_1_to_PLCG_equals_0_when_EGFR_equals_0_and_FGFR3_equals_0] | IS_FIREABLE [FOXO3_equals_0_to_FOXO3_equals_1_when_AKT_equals_0_and_JNK_equals_1]]] & IS_FIREABLE [DUSP1_equals_0_to_DUSP1_equals_1_when_CREB_equals_1]] | ~ [[IS_FIREABLE [AKT_equals_1_to_AKT_equals_0_when_PDK1_equals_0] & IS_FIREABLE [TGFBR_equals_0_to_TGFBR_equals_1_when_TGFBR_stimulus_equals_1]]]]] | ~ [IS_FIREABLE [JUN_equals_1_to_JUN_equals_0_when_JNK_equals_0]]]]]]]]

-> the formula is TRUE

FORMULA MAPKbis-PT-5320-ReachabilityFireability-05 TRUE TECHNIQUES SEQUENTIAL_PROCESSING DECISION_DIAGRAMS UNFOLDING_TO_PT

MC time: 0m 0.001sec

checking: EF [[[[IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1] & [[~ [IS_FIREABLE [MAX_equals_0_to_MAX_equals_1_when_p38_equals_1]] & [~ [[IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_1] | IS_FIREABLE [RSK_equals_0_to_RSK_equals_1_when_ERK_equals_1]]] & ~ [[~ [IS_FIREABLE [MDM2_equals_0_to_MDM2_equals_1_when_AKT_equals_1_and_p14_equals_0]] | [IS_FIREABLE [Proliferation_equals_1_to_Proliferation_equals_0_when_MYC_equals_0] | IS_FIREABLE [GADD45_equals_0_to_GADD45_equals_1_when_p53_equals_1]]]]]] | [[IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_0] & IS_FIREABLE [AP1_equals_0_to_AP1_equals_1_when_ATF2_equals_0_and_FOS_equals_1_and_JUN_equals_1]] | [[[IS_FIREABLE [SOS_equals_1_to_SOS_equals_0_when_RSK_equals_1] | [IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAOK_equals_1] | IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1]]] | [IS_FIREABLE [DUSP1_equals_1_to_DUSP1_equals_0_when_CREB_equals_0] & [IS_FIREABLE [JUN_equals_0_to_JUN_equals_1_when_JNK_equals_1] | IS_FIREABLE [BCL2_equals_1_to_BCL2_equals_0_when_AKT_equals_0]]]] | [~ [[IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_1_and_MDM2_equals_1_and_p38_equals_0] & IS_FIREABLE [MAP3K1_3_equals_0_to_MAP3K1_3_equals_1_when_RAS_equals_1]]] | [~ [IS_FIREABLE [FOXO3_equals_1_to_FOXO3_equals_0_when_JNK_equals_0]] | [IS_FIREABLE [AKT_equals_1_to_AKT_equals_0_when_PTEN_equals_1] | IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1]]]]]]]] | [[~ [[~ [[[IS_FIREABLE [MEK1_2_equals_1_to_MEK1_2_equals_0_when_MAP3K1_3_equals_0_and_RAF_equals_0] & IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_MTK1_equals_1]] & ~ [IS_FIREABLE [MSK_equals_0_to_MSK_equals_1_when_p38_equals_1]]]] & [[[IS_FIREABLE [Apoptosis_equals_1_to_Apoptosis_equals_0_when_ERK_equals_1] & IS_FIREABLE [FRS2_equals_1_to_FRS2_equals_0_when_FGFR3_equals_0]] | IS_FIREABLE [BCL2_equals_1_to_BCL2_equals_0_when_AKT_equals_0]] | [~ [IS_FIREABLE [AP1_equals_0_to_AP1_equals_1_when_ATF2_equals_0_and_FOS_equals_1_and_JUN_equals_1]] | [IS_FIREABLE [p38_equals_1_to_p38_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_0] | IS_FIREABLE [FOS_equals_1_to_FOS_equals_0_when_CREB_equals_0_and_ELK1_equals_0]]]]]] & [[~ [IS_FIREABLE [SMAD_equals_0_to_SMAD_equals_1_when_TGFBR_equals_1]] & IS_FIREABLE [SOS_equals_0_to_SOS_equals_1_when_GRB2_equals_1_and_RSK_equals_0]] | [IS_FIREABLE [DUSP1_equals_1_to_DUSP1_equals_0_when_CREB_equals_0] & [IS_FIREABLE [SMAD_equals_0_to_SMAD_equals_1_when_TGFBR_equals_1] & [[IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_0] | IS_FIREABLE [PI3K_equals_1_to_PI3K_equals_0_when_GAB1_equals_0_and_RAS_equals_0]] | [IS_FIREABLE [Growth_Arrest_equals_0_to_Growth_Arrest_equals_1_when_p21_equals_1] & IS_FIREABLE [GADD45_equals_0_to_GADD45_equals_1_when_SMAD_equals_1]]]]]]] & [[~ [[[IS_FIREABLE [RSK_equals_0_to_RSK_equals_1_when_ERK_equals_1] & IS_FIREABLE [p53_equals_0_to_p53_equals_1_when_ATM_equals_0_and_MDM2_equals_0_and_p38_equals_1]] | ~ [IS_FIREABLE [BCL2_equals_0_to_BCL2_equals_1_when_AKT_equals_1_and_CREB_equals_1]]]] | [~ [[IS_FIREABLE [EGFR_equals_0_to_EGFR_equals_1_when_EGFR_stimulus_equals_0_and_GRB2_equals_0_and_PKC_equals_0_and_SPRY_equals_1] & IS_FIREABLE [PI3K_equals_1_to_PI3K_equals_0_when_GAB1_equals_0_and_RAS_equals_0]]] | IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAOK_equals_1]]] & [[IS_FIREABLE [MYC_equals_0_to_MYC_equals_1_when_AKT_equals_0_and_MAX_equals_1_and_MSK_equals_1] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_MTK1_equals_1]] & IS_FIREABLE [p14_equals_1_to_p14_equals_0_when_MYC_equals_0]]]]] & [[IS_FIREABLE [PI3K_equals_0_to_PI3K_equals_1_when_GAB1_equals_1] & IS_FIREABLE [MAP3K1_3_equals_1_to_MAP3K1_3_equals_0_when_RAS_equals_0]] | [[IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1] & [[IS_FIREABLE [Proliferation_equals_0_to_Proliferation_equals_1_when_MYC_equals_1_and_p21_equals_0_and_p70_equals_1] | IS_FIREABLE [DUSP1_equals_1_to_DUSP1_equals_0_when_CREB_equals_0]] & IS_FIREABLE [PLCG_equals_0_to_PLCG_equals_1_when_FGFR3_equals_1]]] & [[~ [[[[IS_FIREABLE [PKC_equals_0_to_PKC_equals_1_when_PLCG_equals_1] | IS_FIREABLE [SPRY_equals_1_to_SPRY_equals_0_when_ERK_equals_0]] | [IS_FIREABLE [PLCG_equals_1_to_PLCG_equals_0_when_EGFR_equals_0_and_FGFR3_equals_0] | IS_FIREABLE [GADD45_equals_1_to_GADD45_equals_0_when_SMAD_equals_0_and_p53_equals_0]]] | [~ [IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_1]] | ~ [IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1]]]]] | [[[[IS_FIREABLE [TAK1_equals_0_to_TAK1_equals_1_when_TGFBR_equals_1] | IS_FIREABLE [Growth_Arrest_equals_0_to_Growth_Arrest_equals_1_when_p21_equals_1]] & [IS_FIREABLE [RAS_equals_0_to_RAS_equals_1_when_SOS_equals_1] | IS_FIREABLE [AKT_equals_0_to_AKT_equals_1_when_PDK1_equals_1_and_PTEN_equals_0]]] & [[IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAOK_equals_1] | IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1]] & IS_FIREABLE [JUN_equals_0_to_JUN_equals_1_when_JNK_equals_1]]] & [IS_FIREABLE [FGFR3_equals_1_to_FGFR3_equals_0_when_PKC_equals_1] | [[IS_FIREABLE [TAOK_equals_1_to_TAOK_equals_0_when_ATM_equals_0] | IS_FIREABLE [EGFR_equals_0_to_EGFR_equals_1_when_EGFR_stimulus_equals_1_and_GRB2_equals_0_and_PKC_equals_0]] | ~ [IS_FIREABLE [MEK1_2_equals_1_to_MEK1_2_equals_0_when_PPP2CA_equals_1]]]]]] | [[~ [[[IS_FIREABLE [CREB_equals_0_to_CREB_equals_1_when_MSK_equals_1] & IS_FIREABLE [FOXO3_equals_1_to_FOXO3_equals_0_when_JNK_equals_0]] & [IS_FIREABLE [AP1_equals_1_to_AP1_equals_0_when_JUN_equals_0] | IS_FIREABLE [AP1_equals_0_to_AP1_equals_1_when_ATF2_equals_0_and_FOS_equals_1_and_JUN_equals_1]]]] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1]] & [IS_FIREABLE [PDK1_equals_0_to_PDK1_equals_1_when_PI3K_equals_1] | [[IS_FIREABLE [AP1_equals_0_to_AP1_equals_1_when_ATF2_equals_1_and_JUN_equals_1] & IS_FIREABLE [RAF_equals_0_to_RAF_equals_1_when_AKT_equals_0_and_ERK_equals_0_and_RAS_equals_1]] & ~ [IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAOK_equals_0]]]]]]]]]]
normalized: E [true U [[[[[[[[IS_FIREABLE [AP1_equals_0_to_AP1_equals_1_when_ATF2_equals_1_and_JUN_equals_1] & IS_FIREABLE [RAF_equals_0_to_RAF_equals_1_when_AKT_equals_0_and_ERK_equals_0_and_RAS_equals_1]] & ~ [IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAOK_equals_0]]] | IS_FIREABLE [PDK1_equals_0_to_PDK1_equals_1_when_PI3K_equals_1]] & [~ [[[IS_FIREABLE [AP1_equals_1_to_AP1_equals_0_when_JUN_equals_0] | IS_FIREABLE [AP1_equals_0_to_AP1_equals_1_when_ATF2_equals_0_and_FOS_equals_1_and_JUN_equals_1]] & [IS_FIREABLE [CREB_equals_0_to_CREB_equals_1_when_MSK_equals_1] & IS_FIREABLE [FOXO3_equals_1_to_FOXO3_equals_0_when_JNK_equals_0]]]] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1]]] | [[[IS_FIREABLE [FGFR3_equals_1_to_FGFR3_equals_0_when_PKC_equals_1] | [~ [IS_FIREABLE [MEK1_2_equals_1_to_MEK1_2_equals_0_when_PPP2CA_equals_1]] | [IS_FIREABLE [TAOK_equals_1_to_TAOK_equals_0_when_ATM_equals_0] | IS_FIREABLE [EGFR_equals_0_to_EGFR_equals_1_when_EGFR_stimulus_equals_1_and_GRB2_equals_0_and_PKC_equals_0]]]] & [[IS_FIREABLE [JUN_equals_0_to_JUN_equals_1_when_JNK_equals_1] & [IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAOK_equals_1] | IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1]]] & [[IS_FIREABLE [RAS_equals_0_to_RAS_equals_1_when_SOS_equals_1] | IS_FIREABLE [AKT_equals_0_to_AKT_equals_1_when_PDK1_equals_1_and_PTEN_equals_0]] & [IS_FIREABLE [TAK1_equals_0_to_TAK1_equals_1_when_TGFBR_equals_1] | IS_FIREABLE [Growth_Arrest_equals_0_to_Growth_Arrest_equals_1_when_p21_equals_1]]]]] | ~ [[[~ [IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1]] | ~ [IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_1]]] | [[IS_FIREABLE [PLCG_equals_1_to_PLCG_equals_0_when_EGFR_equals_0_and_FGFR3_equals_0] | IS_FIREABLE [GADD45_equals_1_to_GADD45_equals_0_when_SMAD_equals_0_and_p53_equals_0]] | [IS_FIREABLE [PKC_equals_0_to_PKC_equals_1_when_PLCG_equals_1] | IS_FIREABLE [SPRY_equals_1_to_SPRY_equals_0_when_ERK_equals_0]]]]]]] & [IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1] & [IS_FIREABLE [PLCG_equals_0_to_PLCG_equals_1_when_FGFR3_equals_1] & [IS_FIREABLE [Proliferation_equals_0_to_Proliferation_equals_1_when_MYC_equals_1_and_p21_equals_0_and_p70_equals_1] | IS_FIREABLE [DUSP1_equals_1_to_DUSP1_equals_0_when_CREB_equals_0]]]]] | [IS_FIREABLE [PI3K_equals_0_to_PI3K_equals_1_when_GAB1_equals_1] & IS_FIREABLE [MAP3K1_3_equals_1_to_MAP3K1_3_equals_0_when_RAS_equals_0]]] & [[[[IS_FIREABLE [p14_equals_1_to_p14_equals_0_when_MYC_equals_0] & [IS_FIREABLE [MYC_equals_0_to_MYC_equals_1_when_AKT_equals_0_and_MAX_equals_1_and_MSK_equals_1] & IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_MTK1_equals_1]]] & [[IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAOK_equals_1] | ~ [[IS_FIREABLE [EGFR_equals_0_to_EGFR_equals_1_when_EGFR_stimulus_equals_0_and_GRB2_equals_0_and_PKC_equals_0_and_SPRY_equals_1] & IS_FIREABLE [PI3K_equals_1_to_PI3K_equals_0_when_GAB1_equals_0_and_RAS_equals_0]]]] | ~ [[~ [IS_FIREABLE [BCL2_equals_0_to_BCL2_equals_1_when_AKT_equals_1_and_CREB_equals_1]] | [IS_FIREABLE [RSK_equals_0_to_RSK_equals_1_when_ERK_equals_1] & IS_FIREABLE [p53_equals_0_to_p53_equals_1_when_ATM_equals_0_and_MDM2_equals_0_and_p38_equals_1]]]]]] & [[[IS_FIREABLE [DUSP1_equals_1_to_DUSP1_equals_0_when_CREB_equals_0] & [IS_FIREABLE [SMAD_equals_0_to_SMAD_equals_1_when_TGFBR_equals_1] & [[IS_FIREABLE [Growth_Arrest_equals_0_to_Growth_Arrest_equals_1_when_p21_equals_1] & IS_FIREABLE [GADD45_equals_0_to_GADD45_equals_1_when_SMAD_equals_1]] | [IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_0] | IS_FIREABLE [PI3K_equals_1_to_PI3K_equals_0_when_GAB1_equals_0_and_RAS_equals_0]]]]] | [IS_FIREABLE [SOS_equals_0_to_SOS_equals_1_when_GRB2_equals_1_and_RSK_equals_0] & ~ [IS_FIREABLE [SMAD_equals_0_to_SMAD_equals_1_when_TGFBR_equals_1]]]] & ~ [[[[[IS_FIREABLE [p38_equals_1_to_p38_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_0] | IS_FIREABLE [FOS_equals_1_to_FOS_equals_0_when_CREB_equals_0_and_ELK1_equals_0]] | ~ [IS_FIREABLE [AP1_equals_0_to_AP1_equals_1_when_ATF2_equals_0_and_FOS_equals_1_and_JUN_equals_1]]] | [IS_FIREABLE [BCL2_equals_1_to_BCL2_equals_0_when_AKT_equals_0] | [IS_FIREABLE [Apoptosis_equals_1_to_Apoptosis_equals_0_when_ERK_equals_1] & IS_FIREABLE [FRS2_equals_1_to_FRS2_equals_0_when_FGFR3_equals_0]]]] & ~ [[~ [IS_FIREABLE [MSK_equals_0_to_MSK_equals_1_when_p38_equals_1]] & [IS_FIREABLE [MEK1_2_equals_1_to_MEK1_2_equals_0_when_MAP3K1_3_equals_0_and_RAF_equals_0] & IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_MTK1_equals_1]]]]]]]] | [IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1] & [[[[[[IS_FIREABLE [AKT_equals_1_to_AKT_equals_0_when_PTEN_equals_1] | IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1]] | ~ [IS_FIREABLE [FOXO3_equals_1_to_FOXO3_equals_0_when_JNK_equals_0]]] | ~ [[IS_FIREABLE [p53_equals_1_to_p53_equals_0_when_ATM_equals_1_and_MDM2_equals_1_and_p38_equals_0] & IS_FIREABLE [MAP3K1_3_equals_0_to_MAP3K1_3_equals_1_when_RAS_equals_1]]]] | [[IS_FIREABLE [DUSP1_equals_1_to_DUSP1_equals_0_when_CREB_equals_0] & [IS_FIREABLE [JUN_equals_0_to_JUN_equals_1_when_JNK_equals_1] | IS_FIREABLE [BCL2_equals_1_to_BCL2_equals_0_when_AKT_equals_0]]] | [IS_FIREABLE [SOS_equals_1_to_SOS_equals_0_when_RSK_equals_1] | [IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAOK_equals_1] | IS_FIREABLE [p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAOK_equals_1]]]]] | [IS_FIREABLE [JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_0] & IS_FIREABLE [AP1_equals_0_to_AP1_equals_1_when_ATF2_equals_0_and_FOS_equals_1_and_JUN_equals_1]]] | [[~ [[[IS_FIREABLE [Proliferation_equals_1_to_Proliferation_equals_0_when_MYC_equals_0] | IS_FIREABLE [GADD45_equals_0_to_GADD45_equals_1_when_p53_equals_1]] | ~ [IS_FIREABLE [MDM2_equals_0_to_MDM2_equals_1_when_AKT_equals_1_and_p14_equals_0]]]] & ~ [[IS_FIREABLE [JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_1] | IS_FIREABLE [RSK_equals_0_to_RSK_equals_1_when_ERK_equals_1]]]] & ~ [IS_FIREABLE [MAX_equals_0_to_MAX_equals_1_when_p38_equals_1]]]]]]]]

-> the formula is FALSE

FORMULA MAPKbis-PT-5320-ReachabilityFireability-11 FALSE TECHNIQUES SEQUENTIAL_PROCESSING DECISION_DIAGRAMS UNFOLDING_TO_PT

MC time: 0m 0.001sec

totally nodes used: 41239 (4.1e+04)
number of garbage collections: 0
fire ops cache: hits/miss/sum: 74729 266985 341714
used/not used/entry size/cache size: 289165 66819699 16 1024MB
basic ops cache: hits/miss/sum: 18038 58708 76746
used/not used/entry size/cache size: 97528 16679688 12 192MB
unary ops cache: hits/miss/sum: 0 0 0
used/not used/entry size/cache size: 0 16777216 8 128MB
abstract ops cache: hits/miss/sum: 0 0 0
used/not used/entry size/cache size: 0 16777216 12 192MB
state nr cache: hits/miss/sum: 48 235 283
used/not used/entry size/cache size: 235 8388373 32 256MB
max state cache: hits/miss/sum: 0 0 0
used/not used/entry size/cache size: 0 8388608 32 256MB
uniqueHash elements/entry size/size: 67108864 4 256MB
0 67067901
1 40690
2 270
3 3
4 0
5 0
6 0
7 0
8 0
9 0
>= 10 0

Total processing time: 0m 4.463sec


BK_STOP 1679546085233

--------------------
content from stderr:

+ ulimit -s 65536
+ [[ -z '' ]]
+ export LTSMIN_MEM_SIZE=8589934592
+ LTSMIN_MEM_SIZE=8589934592
+ export PYTHONPATH=/home/mcc/BenchKit/itstools/pylibs
+ PYTHONPATH=/home/mcc/BenchKit/itstools/pylibs
+ export LD_LIBRARY_PATH=/home/mcc/BenchKit/itstools/pylibs:
+ LD_LIBRARY_PATH=/home/mcc/BenchKit/itstools/pylibs:
++ sed s/.jar//
++ perl -pe 's/.*\.//g'
++ ls /home/mcc/BenchKit/bin//../reducer/bin//../../itstools//itstools/plugins/fr.lip6.move.gal.application.pnmcc_1.0.0.202303021504.jar
+ VERSION=202303021504
+ echo 'Running Version 202303021504'
+ /home/mcc/BenchKit/bin//../reducer/bin//../../itstools//itstools/its-tools -pnfolder /home/mcc/execution -examination ReachabilityFireability -timeout 360 -rebuildPNML
check for maximal unmarked siphon
found
The net has a maximal unmarked siphon:
PI3K_equals_1
TAK1_equals_1
MAP3K1_3_equals_1
SPRY_equals_1
TGFBR_equals_1
TGFBR_stimulus_equals_1
p70_equals_1
AKT_equals_1
RAS_equals_1
MEK1_2_equals_1
SOS_equals_1
BCL2_equals_1
SMAD_equals_1
EGFR_stimulus_equals_1
DNA_damage_equals_0
FGFR3_equals_1
GAB1_equals_1
FGFR3_stimulus_equals_1
ERK_equals_1
FRS2_equals_1
EGFR_equals_1
RSK_equals_1
PKC_equals_1
GRB2_equals_1
PDK1_equals_1
PLCG_equals_1
RAF_equals_1
FOS_equals_1
Proliferation_equals_1

The net has transition(s) that can never fire:
AKT_equals_1_to_AKT_equals_0_when_PDK1_equals_0
JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAK1_equals_1
JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAOK_equals_1
FGFR3_equals_0_to_FGFR3_equals_1_when_FGFR3_stimulus_equals_1_and_GRB2_equals_0_and_PKC_equals_0
GRB2_equals_0_to_GRB2_equals_1_when_FRS2_equals_1
GRB2_equals_0_to_GRB2_equals_1_when_TGFBR_equals_1
GRB2_equals_1_to_GRB2_equals_0_when_EGFR_equals_0_and_FRS2_equals_0_and_TGFBR_equals_0
MYC_equals_0_to_MYC_equals_1_when_AKT_equals_1_and_MSK_equals_1
GAB1_equals_0_to_GAB1_equals_1_when_PI3K_equals_1
JNK_equals_1_to_JNK_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_0_and_TAK1_equals_0_and_TAOK_equals_0
JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1
p38_equals_1_to_p38_equals_0_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_0_and_TAK1_equals_0_and_TAOK_equals_0
p70_equals_0_to_p70_equals_1_when_ERK_equals_1_and_PDK1_equals_1
p70_equals_1_to_p70_equals_0_when_ERK_equals_0
p70_equals_1_to_p70_equals_0_when_PDK1_equals_0
FOS_equals_1_to_FOS_equals_0_when_CREB_equals_0_and_ELK1_equals_0
SMAD_equals_0_to_SMAD_equals_1_when_TGFBR_equals_1
SMAD_equals_1_to_SMAD_equals_0_when_TGFBR_equals_0
MEK1_2_equals_1_to_MEK1_2_equals_0_when_PPP2CA_equals_1
MSK_equals_0_to_MSK_equals_1_when_ERK_equals_1
MAP3K1_3_equals_0_to_MAP3K1_3_equals_1_when_RAS_equals_1
MAP3K1_3_equals_1_to_MAP3K1_3_equals_0_when_RAS_equals_0
BCL2_equals_1_to_BCL2_equals_0_when_CREB_equals_0
MDM2_equals_0_to_MDM2_equals_1_when_AKT_equals_1_and_p14_equals_0
p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_1
p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAK1_equals_1
p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_TAOK_equals_1
PI3K_equals_1_to_PI3K_equals_0_when_GAB1_equals_0_and_RAS_equals_0
PI3K_equals_1_to_PI3K_equals_0_when_GAB1_equals_0_and_SOS_equals_0
PKC_equals_0_to_PKC_equals_1_when_PLCG_equals_1
PKC_equals_1_to_PKC_equals_0_when_PLCG_equals_0
PLCG_equals_0_to_PLCG_equals_1_when_EGFR_equals_1
GADD45_equals_0_to_GADD45_equals_1_when_SMAD_equals_1
FRS2_equals_0_to_FRS2_equals_1_when_FGFR3_equals_1_and_GRB2_equals_0_and_SPRY_equals_0
FRS2_equals_1_to_FRS2_equals_0_when_FGFR3_equals_0
JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1
ERK_equals_0_to_ERK_equals_1_when_MEK1_2_equals_1
JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_1_and_MTK1_equals_1
EGFR_equals_1_to_EGFR_equals_0_when_EGFR_stimulus_equals_0_and_SPRY_equals_0
FGFR3_equals_1_to_FGFR3_equals_0_when_GRB2_equals_1
FGFR3_equals_1_to_FGFR3_equals_0_when_PKC_equals_1
FOS_equals_0_to_FOS_equals_1_when_CREB_equals_0_and_ELK1_equals_1_and_ERK_equals_1_and_RSK_equals_1
ELK1_equals_0_to_ELK1_equals_1_when_ERK_equals_1
FGFR3_equals_1_to_FGFR3_equals_0_when_FGFR3_stimulus_equals_0
FOS_equals_1_to_FOS_equals_0_when_ERK_equals_0
FOS_equals_1_to_FOS_equals_0_when_RSK_equals_0
FOS_equals_0_to_FOS_equals_1_when_CREB_equals_1_and_ERK_equals_1_and_RSK_equals_1
PDK1_equals_0_to_PDK1_equals_1_when_PI3K_equals_1
PDK1_equals_1_to_PDK1_equals_0_when_PI3K_equals_0
PI3K_equals_0_to_PI3K_equals_1_when_GAB1_equals_1
PI3K_equals_0_to_PI3K_equals_1_when_RAS_equals_1_and_SOS_equals_1
MEK1_2_equals_1_to_MEK1_2_equals_0_when_AP1_equals_1
GAB1_equals_1_to_GAB1_equals_0_when_GRB2_equals_0_and_PI3K_equals_0
MEK1_2_equals_0_to_MEK1_2_equals_1_when_AP1_equals_0_and_MAP3K1_3_equals_0_and_PPP2CA_equals_0_and_RAF_equals_1
MEK1_2_equals_0_to_MEK1_2_equals_1_when_AP1_equals_0_and_MAP3K1_3_equals_1_and_PPP2CA_equals_0
MEK1_2_equals_1_to_MEK1_2_equals_0_when_MAP3K1_3_equals_0_and_RAF_equals_0
FRS2_equals_1_to_FRS2_equals_0_when_GRB2_equals_1
FRS2_equals_1_to_FRS2_equals_0_when_SPRY_equals_1
FOXO3_equals_1_to_FOXO3_equals_0_when_AKT_equals_1
Proliferation_equals_1_to_Proliferation_equals_0_when_MYC_equals_0
Proliferation_equals_1_to_Proliferation_equals_0_when_p21_equals_1
Proliferation_equals_1_to_Proliferation_equals_0_when_p70_equals_0
RAF_equals_0_to_RAF_equals_1_when_AKT_equals_0_and_ERK_equals_0_and_PKC_equals_1
RAF_equals_0_to_RAF_equals_1_when_AKT_equals_0_and_ERK_equals_0_and_RAS_equals_1
EGFR_equals_1_to_EGFR_equals_0_when_GRB2_equals_1
EGFR_equals_1_to_EGFR_equals_0_when_PKC_equals_1
EGFR_equals_0_to_EGFR_equals_1_when_EGFR_stimulus_equals_0_and_GRB2_equals_0_and_PKC_equals_0_and_SPRY_equals_1
Apoptosis_equals_1_to_Apoptosis_equals_0_when_ERK_equals_1
RSK_equals_1_to_RSK_equals_0_when_ERK_equals_0
JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_1_and_TAOK_equals_1
JNK_equals_0_to_JNK_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_1
SOS_equals_0_to_SOS_equals_1_when_GRB2_equals_1_and_RSK_equals_0
SOS_equals_1_to_SOS_equals_0_when_GRB2_equals_0
SOS_equals_1_to_SOS_equals_0_when_RSK_equals_1
SPRY_equals_0_to_SPRY_equals_1_when_ERK_equals_1
RAF_equals_1_to_RAF_equals_0_when_AKT_equals_1
RAF_equals_1_to_RAF_equals_0_when_ERK_equals_1
RAF_equals_1_to_RAF_equals_0_when_PKC_equals_0_and_RAS_equals_0
RAS_equals_0_to_RAS_equals_1_when_PLCG_equals_1
RAS_equals_0_to_RAS_equals_1_when_SOS_equals_1
RAS_equals_1_to_RAS_equals_0_when_PLCG_equals_0_and_SOS_equals_0
RSK_equals_0_to_RSK_equals_1_when_ERK_equals_1
ERK_equals_1_to_ERK_equals_0_when_MEK1_2_equals_0
PLCG_equals_0_to_PLCG_equals_1_when_FGFR3_equals_1
PLCG_equals_1_to_PLCG_equals_0_when_EGFR_equals_0_and_FGFR3_equals_0
Proliferation_equals_0_to_Proliferation_equals_1_when_MYC_equals_1_and_p21_equals_0_and_p70_equals_1
GRB2_equals_0_to_GRB2_equals_1_when_EGFR_equals_1
SPRY_equals_1_to_SPRY_equals_0_when_ERK_equals_0
TAK1_equals_0_to_TAK1_equals_1_when_TGFBR_equals_1
TAK1_equals_1_to_TAK1_equals_0_when_TGFBR_equals_0
TGFBR_equals_0_to_TGFBR_equals_1_when_TGFBR_stimulus_equals_1
TGFBR_equals_1_to_TGFBR_equals_0_when_TGFBR_stimulus_equals_0
p21_equals_1_to_p21_equals_0_when_AKT_equals_1
p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_MAP3K1_3_equals_1
p38_equals_0_to_p38_equals_1_when_DUSP1_equals_0_and_TAK1_equals_1
p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_0_and_TAK1_equals_1_and_TAOK_equals_1
p38_equals_0_to_p38_equals_1_when_DUSP1_equals_1_and_MAP3K1_3_equals_0_and_MTK1_equals_1_and_TAK1_equals_1
AP1_equals_0_to_AP1_equals_1_when_ATF2_equals_0_and_FOS_equals_1_and_JUN_equals_1
EGFR_equals_0_to_EGFR_equals_1_when_EGFR_stimulus_equals_1_and_GRB2_equals_0_and_PKC_equals_0
ATM_equals_1_to_ATM_equals_0_when_DNA_damage_equals_0
BCL2_equals_0_to_BCL2_equals_1_when_AKT_equals_1_and_CREB_equals_1
Apoptosis_equals_1_to_Apoptosis_equals_0_when_BCL2_equals_1
GAB1_equals_0_to_GAB1_equals_1_when_GRB2_equals_1
AKT_equals_1_to_AKT_equals_0_when_PTEN_equals_1
AKT_equals_0_to_AKT_equals_1_when_PDK1_equals_1_and_PTEN_equals_0
BCL2_equals_1_to_BCL2_equals_0_when_AKT_equals_0

check for constant places
DNA_damage_equals_0
DNA_damage_equals_1
EGFR_stimulus_equals_0
EGFR_stimulus_equals_1
FGFR3_stimulus_equals_0
FGFR3_stimulus_equals_1
TGFBR_stimulus_equals_0
TGFBR_stimulus_equals_1
found 8 constant places
check if there are places and transitions
ok
check if there are transitions without pre-places
ok
check if at least one transition is enabled in m0
ok
check if there are transitions that can never fire
ok


initing FirstDep: 0m 0.001sec


iterations count:3466 (20), effective:182 (1)

initing FirstDep: 0m 0.000sec


iterations count:1057 (6), effective:45 (0)

iterations count:1891 (10), effective:98 (0)

Sequence of Actions to be Executed by the VM

This is useful if one wants to reexecute the tool in the VM from the submitted image disk.

set -x
# this is for BenchKit: configuration of major elements for the test
export BK_INPUT="MAPKbis-PT-5320"
export BK_EXAMINATION="ReachabilityFireability"
export BK_TOOL="marciexred"
export BK_RESULT_DIR="/tmp/BK_RESULTS/OUTPUTS"
export BK_TIME_CONFINEMENT="3600"
export BK_MEMORY_CONFINEMENT="16384"
export BK_BIN_PATH="/home/mcc/BenchKit/bin/"

# this is specific to your benchmark or test

export BIN_DIR="$HOME/BenchKit/bin"

# remove the execution directoty if it exists (to avoid increse of .vmdk images)
if [ -d execution ] ; then
rm -rf execution
fi

# this is for BenchKit: explicit launching of the test
echo "====================================================================="
echo " Generated by BenchKit 2-5348"
echo " Executing tool marciexred"
echo " Input is MAPKbis-PT-5320, examination is ReachabilityFireability"
echo " Time confinement is $BK_TIME_CONFINEMENT seconds"
echo " Memory confinement is 16384 MBytes"
echo " Number of cores is 4"
echo " Run identifier is r234-tall-167856420600647"
echo "====================================================================="
echo
echo "--------------------"
echo "preparation of the directory to be used:"

tar xzf /home/mcc/BenchKit/INPUTS/MAPKbis-PT-5320.tgz
mv MAPKbis-PT-5320 execution
cd execution
if [ "ReachabilityFireability" = "ReachabilityDeadlock" ] || [ "ReachabilityFireability" = "UpperBounds" ] || [ "ReachabilityFireability" = "QuasiLiveness" ] || [ "ReachabilityFireability" = "StableMarking" ] || [ "ReachabilityFireability" = "Liveness" ] || [ "ReachabilityFireability" = "OneSafe" ] || [ "ReachabilityFireability" = "StateSpace" ]; then
rm -f GenericPropertiesVerdict.xml
fi
pwd
ls -lh

echo
echo "--------------------"
echo "content from stdout:"
echo
echo "=== Data for post analysis generated by BenchKit (invocation template)"
echo
if [ "ReachabilityFireability" = "UpperBounds" ] ; then
echo "The expected result is a vector of positive values"
echo NUM_VECTOR
elif [ "ReachabilityFireability" != "StateSpace" ] ; then
echo "The expected result is a vector of booleans"
echo BOOL_VECTOR
else
echo "no data necessary for post analysis"
fi
echo
if [ -f "ReachabilityFireability.txt" ] ; then
echo "here is the order used to build the result vector(from text file)"
for x in $(grep Property ReachabilityFireability.txt | cut -d ' ' -f 2 | sort -u) ; do
echo "FORMULA_NAME $x"
done
elif [ -f "ReachabilityFireability.xml" ] ; then # for cunf (txt files deleted;-)
echo echo "here is the order used to build the result vector(from xml file)"
for x in $(grep '' ReachabilityFireability.xml | cut -d '>' -f 2 | cut -d '<' -f 1 | sort -u) ; do
echo "FORMULA_NAME $x"
done
elif [ "ReachabilityFireability" = "ReachabilityDeadlock" ] || [ "ReachabilityFireability" = "QuasiLiveness" ] || [ "ReachabilityFireability" = "StableMarking" ] || [ "ReachabilityFireability" = "Liveness" ] || [ "ReachabilityFireability" = "OneSafe" ] ; then
echo "FORMULA_NAME ReachabilityFireability"
fi
echo
echo "=== Now, execution of the tool begins"
echo
echo -n "BK_START "
date -u +%s%3N
echo
timeout -s 9 $BK_TIME_CONFINEMENT bash -c "/home/mcc/BenchKit/BenchKit_head.sh 2> STDERR ; echo ; echo -n \"BK_STOP \" ; date -u +%s%3N"
if [ $? -eq 137 ] ; then
echo
echo "BK_TIME_CONFINEMENT_REACHED"
fi
echo
echo "--------------------"
echo "content from stderr:"
echo
cat STDERR ;